![](/images/graphics-bg.png)
Remarkable Anti-Trichomonas vaginalis Activity of Plants Traditionally Used by the Mbyá-Guarani Indigenous Group in Brazil
Joint Authors
Brandelli, Clara Lia Costa
Vieira, Patrícia de Brum
Tasca, Tiana
Macedo, Alexandre José
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Trichomonas vaginalis, a flagellate protozoan, is the causative agent of trichomonosis, the most common nonviral sexually transmitted disease worldwide.
Taking into account the increased prevalence of metronidazole-resistant isolates, alternative drugs are essential for the successful treatment.
Natural products are the source of most new drugs, and popular wisdom about the use of medicinal plants is a powerful tool in this search.
In this study, the activity of 10 medicinal plants extensively used in daily life by Mbyá-Guarani indigenous group was evaluated against seven different T.
vaginalis isolates.
Among the aqueous extracts tested, Verbena sp.
(Guachu ka'a in Mbyá-Guarani language) and Campomanesia xanthocarpa (Guavira in Mbyá-Guarani language) showed the highest activity against T.
vaginalis with MIC value of 4.0 mg/mL reaching 100% of efficacy against the parasite.
The kinetic growth assays showed that the extracts promoted complete growth abolishment after 4 h of incubation.
In addition, the extracts tested did not promote a significant hemolytic activity against human erythrocytes.
Our results show for the first time the potential activity of Verbena sp.
and C.
xanthocarpa against T.
vaginalis.
In addition, this study demonstrates that indigenous knowledge is an important source of new prototype antiprotozoal agents.
American Psychological Association (APA)
Brandelli, Clara Lia Costa& Vieira, Patrícia de Brum& Macedo, Alexandre José& Tasca, Tiana. 2013. Remarkable Anti-Trichomonas vaginalis Activity of Plants Traditionally Used by the Mbyá-Guarani Indigenous Group in Brazil. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030958
Modern Language Association (MLA)
Brandelli, Clara Lia Costa…[et al.]. Remarkable Anti-Trichomonas vaginalis Activity of Plants Traditionally Used by the Mbyá-Guarani Indigenous Group in Brazil. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030958
American Medical Association (AMA)
Brandelli, Clara Lia Costa& Vieira, Patrícia de Brum& Macedo, Alexandre José& Tasca, Tiana. Remarkable Anti-Trichomonas vaginalis Activity of Plants Traditionally Used by the Mbyá-Guarani Indigenous Group in Brazil. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030958
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030958