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Effect of the Plasmid-DNA Vaccination on Macroscopic and Microscopic Damage Caused by the Experimental Chronic Trypanosoma cruzi Infection in the Canine Model
Joint Authors
Rosales-Encina, José Luis
Vallejo, Maite
Rodríguez-Morales, Olivia
Carrillo-Sánchez, Silvia C.
García-Mendoza, Humberto
Aranda-Fraustro, Alberto
Ballinas-Verdugo, Martha A.
Alejandre-Aguilar, Ricardo
Arce-Fonseca, Minerva
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The dog is considered the main domestic reservoir for Trypanosoma cruzi infection and a suitable experimental animal model to study the pathological changes during the course of Chagas disease (CD).
Vaccine development is one of CD prevention methods to protect people at risk.
Two plasmids containing genes encoding a trans-sialidase protein (TcSP) and an amastigote-specific glycoprotein (TcSSP4) were used as DNA vaccines in a canine model.
Splenomegaly was not found in either of the recombinant plasmid-immunized groups; however, cardiomegaly was absent in animals immunized only with the plasmid containing the TcSSP4 gene.
The inflammation of subendocardial and myocardial tissues was prevented only with the immunization with TcSSP4 gene.
In conclusion, the vaccination with these genes has a partial protective effect on the enlargement of splenic and cardiac tissues during the chronic CD and on microscopic hearth damage, since both plasmids prevented splenomegaly but only one avoided cardiomegaly, and the lesions in heart tissue of dog immunized with plasmid containing the TcSSP4 gene covered only subepicardial tissue.
American Psychological Association (APA)
Rodríguez-Morales, Olivia& Carrillo-Sánchez, Silvia C.& García-Mendoza, Humberto& Aranda-Fraustro, Alberto& Ballinas-Verdugo, Martha A.& Alejandre-Aguilar, Ricardo…[et al.]. 2013. Effect of the Plasmid-DNA Vaccination on Macroscopic and Microscopic Damage Caused by the Experimental Chronic Trypanosoma cruzi Infection in the Canine Model. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030959
Modern Language Association (MLA)
Rodríguez-Morales, Olivia…[et al.]. Effect of the Plasmid-DNA Vaccination on Macroscopic and Microscopic Damage Caused by the Experimental Chronic Trypanosoma cruzi Infection in the Canine Model. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030959
American Medical Association (AMA)
Rodríguez-Morales, Olivia& Carrillo-Sánchez, Silvia C.& García-Mendoza, Humberto& Aranda-Fraustro, Alberto& Ballinas-Verdugo, Martha A.& Alejandre-Aguilar, Ricardo…[et al.]. Effect of the Plasmid-DNA Vaccination on Macroscopic and Microscopic Damage Caused by the Experimental Chronic Trypanosoma cruzi Infection in the Canine Model. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030959
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030959