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Osteogenic Matrix Cell Sheet Transplantation Enhances Early Tendon Graft to Bone Tunnel Healing in Rabbits
Joint Authors
Morita, Yusuke
Inagaki, Yusuke
Uematsu, Kota
Akahane, Manabu
Ogawa, Munehiro
Ueha, Tomoyuki
Shimizu, Takamasa
Kura, Tomohiko
Kawate, Kenji
Tanaka, Yasuhito
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The objective of this study was to determine whether osteogenic matrix cell sheets (OMCS) could induce bone formation around grafted tendons, thereby enhancing early stage tendon to bone tunnel healing in skeletally mature male Japanese white rabbits.
First, the osteogenic potential of rabbit OMCS was evaluated.
Then, the OMCS were transplanted into the interface between the grafted tendon and the bone tunnel created at the tibia.
Histological assessments and biomechanical tensile testing were performed after 3 weeks.
The rabbit OMCS showed high alkaline phosphatase (ALP) activity, positive staining of ALP, and osteogenic potential when transplanted subcutaneously with beta tricalcium phosphate disks.
Newly formed bony walls and positive collagen type I staining were seen around the grafted tendon with OMCS transplantation, whereas such bony walls were thinner or less frequent without OMCS transplantation.
Micro-computed tomography images showed significantly higher bone volume in the OMCS transplantation group.
The pullout strength was significantly higher with OMCS (0.74±0.23 N/mm2) than without OMCS (0.58±0.15 N/mm2).
These results show that OMCS enhance early tendon to bone tunnel healing.
This method can be applied to cases requiring early tendon to bone tunnel healing after ligament reconstruction surgery.
American Psychological Association (APA)
Inagaki, Yusuke& Uematsu, Kota& Akahane, Manabu& Morita, Yusuke& Ogawa, Munehiro& Ueha, Tomoyuki…[et al.]. 2013. Osteogenic Matrix Cell Sheet Transplantation Enhances Early Tendon Graft to Bone Tunnel Healing in Rabbits. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030990
Modern Language Association (MLA)
Inagaki, Yusuke…[et al.]. Osteogenic Matrix Cell Sheet Transplantation Enhances Early Tendon Graft to Bone Tunnel Healing in Rabbits. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030990
American Medical Association (AMA)
Inagaki, Yusuke& Uematsu, Kota& Akahane, Manabu& Morita, Yusuke& Ogawa, Munehiro& Ueha, Tomoyuki…[et al.]. Osteogenic Matrix Cell Sheet Transplantation Enhances Early Tendon Graft to Bone Tunnel Healing in Rabbits. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030990
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030990