Expression of Melatonin Synthesizing Enzymes in Helicobacter pylori Infected Gastric Mucosa
Joint Authors
Blasiak, Janusz
Popławski, Tomasz
Chojnacki, Jan
Klupinska, Grazyna
Chojnacki, Jan
Reiter, Russel J.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Helicobacter pylori colonization of gastric mucosa causes pain of unknown etiology in about 15–20% of infected subjects.
The aim of the present work was to determine the level of expression of enzymes involved in the synthesis of melatonin in gastric mucosa of asymptomatic and symptomatic H.
pylori infected patients.
To diagnose H.
pylori infection, histological analysis and the urea breath test (UBT C13) were performed.
The levels of mRNA expression of arylalkylamine-N-acetyltransferase (AA-NAT) and acetylserotonin methyltransferase (ASMT) were estimated in gastric mucosa with RT-PCR.
The level of AA-NAT expression and AMST was decreased in H.
pylori infected patients and was increased after H.
pylori eradication.
We conclude that decreased expression of melatonin synthesizing enzymes, AA-NAT and ASMT, in patients with symptomatic H.
pylori infection returns to normal level after H.
pylori eradication.
American Psychological Association (APA)
Chojnacki, Jan& Popławski, Tomasz& Blasiak, Janusz& Chojnacki, Jan& Reiter, Russel J.& Klupinska, Grazyna. 2013. Expression of Melatonin Synthesizing Enzymes in Helicobacter pylori Infected Gastric Mucosa. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030997
Modern Language Association (MLA)
Chojnacki, Jan…[et al.]. Expression of Melatonin Synthesizing Enzymes in Helicobacter pylori Infected Gastric Mucosa. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030997
American Medical Association (AMA)
Chojnacki, Jan& Popławski, Tomasz& Blasiak, Janusz& Chojnacki, Jan& Reiter, Russel J.& Klupinska, Grazyna. Expression of Melatonin Synthesizing Enzymes in Helicobacter pylori Infected Gastric Mucosa. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030997
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030997