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Endothelial Progenitor Cell Dysfunction in Cardiovascular Diseases: Role of Reactive Oxygen Species and Inflammation
Joint Authors
Liu, Po-Len
Chen, Huey-Yi
Chen, Wen-Chi
Lin, Feng-Yen
Huang, P.-H.
Lin, Chih-Pei
Huang, Yu-Chuen
Liao, Wen-Ling
Chen, Yuh-Lien
Huang, Huey-Chun
Chen, Yung-Hsiang
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Endothelial progenitor cells (EPCs) move towards injured endothelium or inflamed tissues and incorporate into foci of neovascularisation, thereby improving blood flow and tissue repair.
Patients with cardiovascular diseases have been shown to exhibit reduced EPC number and function.
It has become increasingly apparent that these changes may be effected in response to enhanced oxidative stress, possibly as a result of systemic and localised inflammatory responses.
The interplay between inflammation and oxidative stress affects the initiation, progression, and complications of cardiovascular diseases.
Recent studies suggest that inflammation and oxidative stress modulate EPC bioactivity.
Clinical medications with anti-inflammatory and antioxidant properties, such as statins, thiazolidinediones, angiotensin II receptor 1 blockers, and angiotensin-converting enzyme inhibitors, are currently administered to patients with cardiovascular diseases.
These medications appear to exert beneficial effects on EPC biology.
This review focuses on EPC biology and explores the links between oxidative stress, inflammation, and development of cardiovascular diseases.
American Psychological Association (APA)
Lin, Chih-Pei& Lin, Feng-Yen& Huang, P.-H.& Chen, Yuh-Lien& Chen, Wen-Chi& Chen, Huey-Yi…[et al.]. 2012. Endothelial Progenitor Cell Dysfunction in Cardiovascular Diseases: Role of Reactive Oxygen Species and Inflammation. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030999
Modern Language Association (MLA)
Lin, Chih-Pei…[et al.]. Endothelial Progenitor Cell Dysfunction in Cardiovascular Diseases: Role of Reactive Oxygen Species and Inflammation. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1030999
American Medical Association (AMA)
Lin, Chih-Pei& Lin, Feng-Yen& Huang, P.-H.& Chen, Yuh-Lien& Chen, Wen-Chi& Chen, Huey-Yi…[et al.]. Endothelial Progenitor Cell Dysfunction in Cardiovascular Diseases: Role of Reactive Oxygen Species and Inflammation. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030999
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030999