TLR Stimulation of Bone Marrow Lymphoid Precursors from Childhood Acute Leukemia Modifies Their Differentiation Potentials
Joint Authors
Mayani, Hector
Vadillo, Eduardo
Jiménez-Hernández, Elva
Purizaca, Jessica
Arriaga-Pizano, Lourdes
Balandrán, Juan Carlos
Aguilera, Wendy
Medina-Sanson, Aurora
Pelayo, Rosana
Huerta-Yepez, Sara
Contreras-Quiroz, Adriana
Dorantes-Acosta, Elisa María
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Acute leukemias are the most frequent childhood malignancies worldwide and remain a leading cause of morbidity and mortality of relapsed patients.
While remarkable progress has been made in characterizing genetic aberrations that may control these hematological disorders, it has also become clear that abnormalities in the bone marrow microenvironment might hit precursor cells and contribute to disease.
However, responses of leukemic precursor cells to inflammatory conditions or microbial components upon infection are yet unexplored.
Our previous work and increasing evidence indicate that Toll-like receptors (TLRs) in the earliest stages of lymphoid development in mice and humans provide an important mechanism for producing cells of the innate immune system.
Using highly controlled co-culture systems, we now show that lymphoid precursors from leukemic bone marrow express TLRs and respond to their ligation by changing cell differentiation patterns.
While no apparent contribution of TLR signals to tumor progression was recorded for any of the investigated diseases, the replenishment of innate cells was consistently promoted upon in vitro TLR exposure, suggesting that early recognition of pathogen-associated molecules might be implicated in the regulation of hematopoietic cell fate decisions in childhood acute leukemia.
American Psychological Association (APA)
Dorantes-Acosta, Elisa María& Vadillo, Eduardo& Contreras-Quiroz, Adriana& Balandrán, Juan Carlos& Arriaga-Pizano, Lourdes& Purizaca, Jessica…[et al.]. 2013. TLR Stimulation of Bone Marrow Lymphoid Precursors from Childhood Acute Leukemia Modifies Their Differentiation Potentials. BioMed Research International،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1031001
Modern Language Association (MLA)
Dorantes-Acosta, Elisa María…[et al.]. TLR Stimulation of Bone Marrow Lymphoid Precursors from Childhood Acute Leukemia Modifies Their Differentiation Potentials. BioMed Research International No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-1031001
American Medical Association (AMA)
Dorantes-Acosta, Elisa María& Vadillo, Eduardo& Contreras-Quiroz, Adriana& Balandrán, Juan Carlos& Arriaga-Pizano, Lourdes& Purizaca, Jessica…[et al.]. TLR Stimulation of Bone Marrow Lymphoid Precursors from Childhood Acute Leukemia Modifies Their Differentiation Potentials. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1031001
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031001