Risk Factors for the First Episode of Klebsiella pneumoniae Resistant to Carbapenems Infection in Critically Ill Patients: A Prospective Study
Joint Authors
Mantzarlis, Konstantinos
Manoulakas, Efstratios
Karvouniaris, Marios
Zakynthinos, Epaminondas
Makris, Demosthenes
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To identify risk factors for the first episode of Klebsiella Pneumonia resistant to carbapenems (KPRC) infection in critically ill patients.
Design, Setting, and Methods.
This prospective cohort study was conducted in a 12-bed general Intensive Care Unit (ICU) in a University Hospital on ICU patients who required mechanical ventilation (MV) for >48 hours during a 12-month period.
Clinical and microbiologic data were studied.
Characteristics of KPRC patients were compared with those of critically ill patients who presented nonmultidrug resistant (MDR) bacterial infections or no documented infection at all.
Results.
Twenty-five patients presented KPRC infection, 18 presented non-MDR bacterial infection, and 39 patients presented no infection.
Compared to patients without documented infection or infected by non MDR bacteria, patients with KPRC infection had received more frequently or for longer duration antibiotics against Gram-negative bacteria (carbapenems, colistin P<0.05).
Duration of colistin administration prior to KPRC isolation was independently associated with increased frequency of KPRC infection (odds ratio, 1.156 per day; 95% confidence interval, 1.010 to 1.312; P=0.025).
KPRC patients stayed longer in the ICU and received mechanical ventilation and sedation for longer periods and presented increased mortality (P<0.05).
Conclusion.
KPRC infection is an emerging problem which might be more common in patients with previous use of antibiotics and especially colistin.
American Psychological Association (APA)
Mantzarlis, Konstantinos& Makris, Demosthenes& Manoulakas, Efstratios& Karvouniaris, Marios& Zakynthinos, Epaminondas. 2013. Risk Factors for the First Episode of Klebsiella pneumoniae Resistant to Carbapenems Infection in Critically Ill Patients: A Prospective Study. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1031021
Modern Language Association (MLA)
Mantzarlis, Konstantinos…[et al.]. Risk Factors for the First Episode of Klebsiella pneumoniae Resistant to Carbapenems Infection in Critically Ill Patients: A Prospective Study. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1031021
American Medical Association (AMA)
Mantzarlis, Konstantinos& Makris, Demosthenes& Manoulakas, Efstratios& Karvouniaris, Marios& Zakynthinos, Epaminondas. Risk Factors for the First Episode of Klebsiella pneumoniae Resistant to Carbapenems Infection in Critically Ill Patients: A Prospective Study. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1031021
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031021