![](/images/graphics-bg.png)
The Evolutionary Pattern and the Regulation of Stearoyl-CoA Desaturase Genes
Joint Authors
Huang, Jing-Fei
Wu, Xiaoyun
Zou, Xiaoju
Chang, Qing
Zhang, Yuru
Li, Yunhai
Zhang, Linqiang
Liang, Bin
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Stearoyl-CoA desaturase (SCD) is a key enzyme that converts saturated fatty acids (SFAs) to monounsaturated fatty acids (MUFAs) in the biosynthesis of fat.
To date, two isoforms of scd gene (scd1 and scd5) have been found widely existent in most of the vertebrate animals.
However, the evolutionary patterns of both isofoms and the function of scd5 are poorly understandable.
Herein, we aim to characterize the evolutionary pattern of scd genes and further predict the function differentiation of scd genes.
The sequences of scd genes were highly conserved among eukaryote.
Phylogenetic analysis identified two duplications of scd gene early in vertebrate evolution.
The relative rate ratio test, branch-specific dN/dS ratio tests, and branch-site dN/dS ratio tests all suggested that the scd genes were evolved at a similar rate.
The evolution of scd genes among eukaryote was under strictly purifying selection though several sites in scd1 and scd5 were undergone a relaxed selection pressure.
The variable binding sites by transcriptional factors at the 5′-UTR and by miRNAs at 3′-UTR of scd genes suggested that the regulators of scd5 may be different from that of scd1.
This study promotes our understanding of the evolutionary patterns and function of SCD genes in eukaryote.
American Psychological Association (APA)
Wu, Xiaoyun& Zou, Xiaoju& Chang, Qing& Zhang, Yuru& Li, Yunhai& Zhang, Linqiang…[et al.]. 2013. The Evolutionary Pattern and the Regulation of Stearoyl-CoA Desaturase Genes. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1031030
Modern Language Association (MLA)
Wu, Xiaoyun…[et al.]. The Evolutionary Pattern and the Regulation of Stearoyl-CoA Desaturase Genes. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1031030
American Medical Association (AMA)
Wu, Xiaoyun& Zou, Xiaoju& Chang, Qing& Zhang, Yuru& Li, Yunhai& Zhang, Linqiang…[et al.]. The Evolutionary Pattern and the Regulation of Stearoyl-CoA Desaturase Genes. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1031030
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031030