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Coagulation Proteins Influencing Global Coagulation Assays in Cirrhosis: Hypercoagulability in Cirrhosis Assessed by Thrombomodulin-Induced Thrombin Generation Assay
Joint Authors
Youngwon, Nam
Kim, Ji-Eun
Lim, Hae Sook
Kim, Hyun Kyung
Han, Kyou-Sup
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Liver disease is accompanied by profound hemostatic disturbances.
We investigated the influences of pro- and anticoagulation factors on global coagulation tests including prothrombin time (PT), activated partial thromboplastin time (aPTT), and thrombin generation assay (TGA) in cirrhosis.
We also investigated whether cirrhotic patients exhibit hypo- or hypercoagulability using the TGA.
Methods.
The TGA was performed on a calibrated automated thrombogram, given lag time, endogenous thrombin potential (ETP), and peak thrombin in 156 cirrhotic patients and 73 controls.
Results.
PT was determined according to the factor (F) II, FV, FVII, FIX, and protein C levels.
We observed that aPTT was dependent on FII, FIX, and FX levels.
The ETP was dependent on FII, antithrombin, and protein C with 5 pM tissue factor (TF) stimulation, and FIX and protein C at 1 pM TF.
The ETP ratio with 1 pM TF increased significantly in cirrhosis, indicating hypercoagulability, whereas that with 5 pM TF did not increase in cirrhosis.
Conclusion.
PT and the TGA are sensitive to protein C levels.
Even with prolonged PT, the TGA can detect hypercoagulability in cirrhosis.
Further studies should evaluate global coagulation status in cirrhosis patients using the newly devised TGA system.
American Psychological Association (APA)
Youngwon, Nam& Kim, Ji-Eun& Lim, Hae Sook& Han, Kyou-Sup& Kim, Hyun Kyung. 2013. Coagulation Proteins Influencing Global Coagulation Assays in Cirrhosis: Hypercoagulability in Cirrhosis Assessed by Thrombomodulin-Induced Thrombin Generation Assay. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031031
Modern Language Association (MLA)
Youngwon, Nam…[et al.]. Coagulation Proteins Influencing Global Coagulation Assays in Cirrhosis: Hypercoagulability in Cirrhosis Assessed by Thrombomodulin-Induced Thrombin Generation Assay. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1031031
American Medical Association (AMA)
Youngwon, Nam& Kim, Ji-Eun& Lim, Hae Sook& Han, Kyou-Sup& Kim, Hyun Kyung. Coagulation Proteins Influencing Global Coagulation Assays in Cirrhosis: Hypercoagulability in Cirrhosis Assessed by Thrombomodulin-Induced Thrombin Generation Assay. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031031
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031031