![](/images/graphics-bg.png)
Chronic Stress Induces Structural Alterations in Splenic Lymphoid Tissue That Are Associated with Changes in Corticosterone Levels in Wistar-Kyoto Rats
Joint Authors
Perez-Tapia, S. M.
Salinas-Lara, Citlaltepetl
Morales-Montor, Jorge
Martínez-Mota, Lucía
Hernandez, María Eugenia
Marquez-Velasco, Ricardo
Hernandez-Chan, Nancy G.
Streber, María L.
Granados-Camacho, Ivonne
Becerril, Enrique
Javier, Baquera-Heredia
Pavon, Lenin
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Major depressive disorder patients present chronic stress and decreased immunity.
The Wistar-Kyoto rat (WKY) is a strain in which the hypothalamic-pituitary-adrenal axis is overactivated.
To determine whether chronic stress induces changes in corticosterone levels and splenic lymphoid tissue, 9-week-old male rats were subject to restraint stress (3 h daily), chemical stress (hydrocortisone treatment, 50 mg/Kg weight), mixed stress (restraint plus hydrocortisone), or control treatment (without stress) for 1, 4, and 7 weeks.
The serum corticosterone levels by RIA and spleens morphology were analyzed.
Corticosterone levels as did the structure, size of the follicles and morphology of the parenchyma (increase in red pulp) in the spleen, varied depending on time and type of stressor.
These changes indicate that chronic stress alters the immune response in the spleen in WKY rats by inducing morphological changes, explaining in part the impaired immunity that develops in organisms that are exposed to chronic stress.
American Psychological Association (APA)
Hernandez, María Eugenia& Martínez-Mota, Lucía& Salinas-Lara, Citlaltepetl& Marquez-Velasco, Ricardo& Hernandez-Chan, Nancy G.& Morales-Montor, Jorge…[et al.]. 2013. Chronic Stress Induces Structural Alterations in Splenic Lymphoid Tissue That Are Associated with Changes in Corticosterone Levels in Wistar-Kyoto Rats. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031042
Modern Language Association (MLA)
Hernandez, María Eugenia…[et al.]. Chronic Stress Induces Structural Alterations in Splenic Lymphoid Tissue That Are Associated with Changes in Corticosterone Levels in Wistar-Kyoto Rats. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1031042
American Medical Association (AMA)
Hernandez, María Eugenia& Martínez-Mota, Lucía& Salinas-Lara, Citlaltepetl& Marquez-Velasco, Ricardo& Hernandez-Chan, Nancy G.& Morales-Montor, Jorge…[et al.]. Chronic Stress Induces Structural Alterations in Splenic Lymphoid Tissue That Are Associated with Changes in Corticosterone Levels in Wistar-Kyoto Rats. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031042
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031042