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Gene Expression Profiling of Human Oocytes Developed and Matured In Vivo or In Vitro
Joint Authors
Skutella, Thomas
Knez, Katja
Tomazevic, Tomaz
Virant-Klun, Irma
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-20
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
The quality of the human oocyte determines the success of fertilization and affects the consequent embryo development, pregnancy and birth; it therefore serves as a basis for human reproduction and fertility.
The possibility to evaluate oocyte quality in the in vitro fertilization programme is very limited.
The only criterion which is commonly used to evaluate oocyte quality is its morphology.
There is a mass of oocytes in the in vitro fertilization programme which are not fertilized in spite of normal morphology.
In the past, several attempts focused on oocyte gene expression profiling by different approaches.
The results elucidated groups of genes related to the human oocyte.
It was confirmed that some factors, such as oocyte in vitro maturation, are detectable at the molecular level of human oocytes and their polar bodies in terms of gene expression profile.
Furthermore, the first genetic evaluations of oocyte-like cells developed in vitro from human stem cells of different origin were performed showing that these cells express some genes related to oocytes.
All these findings provide some new knowledge and clearer insights into oocyte quality and oogenesis that might be introduced into clinical practice in the future.
American Psychological Association (APA)
Virant-Klun, Irma& Knez, Katja& Tomazevic, Tomaz& Skutella, Thomas. 2013. Gene Expression Profiling of Human Oocytes Developed and Matured In Vivo or In Vitro. BioMed Research International،Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-1031051
Modern Language Association (MLA)
Virant-Klun, Irma…[et al.]. Gene Expression Profiling of Human Oocytes Developed and Matured In Vivo or In Vitro. BioMed Research International No. 2013 (2013), pp.1-20.
https://search.emarefa.net/detail/BIM-1031051
American Medical Association (AMA)
Virant-Klun, Irma& Knez, Katja& Tomazevic, Tomaz& Skutella, Thomas. Gene Expression Profiling of Human Oocytes Developed and Matured In Vivo or In Vitro. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-1031051
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031051