Serum Brain-Derived Neurotrophic Factor Levels in Different Neurological Diseases
Joint Authors
Bocchio-Chiavetto, Luisella
Ventriglia, Mariacarla
Zanardini, Roberta
Bonomini, Cristina
Volpe, Daniele
Gennarelli, Massimo
Zanetti, O.
Pasqualetti, Patrizio
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Consistent evidence indicates the involvement of the brain-derived neurotrophic factor (BDNF) in neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson’s disease (PD).
In the present study, we compared serum BDNF in 624 subjects: 266 patients affected by AD, 28 by frontotemporal dementia (FTD), 40 by Lewy body dementia (LBD), 91 by vascular dementia (VAD), 30 by PD, and 169 controls.
Our results evidenced lower BDNF serum levels in AD, FTD, LBD, and VAD patients (P<0.001) and a higher BDNF concentration in patients affected by PD (P=0.045).
Analyses of effects of pharmacological treatments suggested significantly higher BDNF serum levels in patients taking mood stabilizers/antiepileptics (P=0.009) and L-DOPA (P<0.001) and significant reductions in patients taking benzodiazepines (P=0.020).
In conclusion, our results support the role of BDNF alterations in neurodegenerative mechanisms common to different forms of neurological disorders and underline the importance of including drug treatment in the analyses to avoid confounding effects.
American Psychological Association (APA)
Ventriglia, Mariacarla& Zanardini, Roberta& Bonomini, Cristina& Zanetti, O.& Volpe, Daniele& Pasqualetti, Patrizio…[et al.]. 2013. Serum Brain-Derived Neurotrophic Factor Levels in Different Neurological Diseases. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031058
Modern Language Association (MLA)
Ventriglia, Mariacarla…[et al.]. Serum Brain-Derived Neurotrophic Factor Levels in Different Neurological Diseases. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1031058
American Medical Association (AMA)
Ventriglia, Mariacarla& Zanardini, Roberta& Bonomini, Cristina& Zanetti, O.& Volpe, Daniele& Pasqualetti, Patrizio…[et al.]. Serum Brain-Derived Neurotrophic Factor Levels in Different Neurological Diseases. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031058
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031058