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Cytogenetic Abnormality in Exfoliated Cells of Buccal Mucosa in Head and Neck Cancer Patients in the Tunisian Population: Impact of Different Exposure Sources
Joint Authors
Rebaï, Ahmed
Khlifi, Rim
Trabelsi-Ksibi, Fatma
Chakroun, Amine
Hamza-Chaffai, Amel
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Chromosome/DNA instability could be one of the primary causes of malignant cell transformation.
The objective of the present study was to evaluate the spontaneous genetic damages in exfoliated cells of buccal mucosa of head and neck cancer (HNC) by counting micronucleus (MN) and binucleated (BN) cells frequencies.
MN and BN frequencies were significantly increased in HNC patients compared with controls (5.53 ± 3.09/1000 cells, 5.63 ± 2.99/1000 cells versus 2.36 ± 2.11/1000 cells, 3.09 ± 1.82/1000 cells, P<0.001).
Regarding the gender and the age, the frequencies of the MN and BN were significantly higher than those of controls (P<0.01).
The evaluation of the MN and BN frequencies revealed a significant increase (P<0.001) in the cases in relation to the control group after controlling the risk factors (tobacco smoking and chewing and occupational exposure) of HNC.
Moreover, MN and BN frequencies were significantly increased in smokers and chewers compared with nonsmokers and nonchewers among patients (P<0.05).
MN frequency was significantly (P=0.014) different between patients occupationally exposed (6.99 ± 3.40/1000 cells) and nonexposed (4.70 ± 2.48/1000 cells) among HNC group.
The logistic regression model illustrated that HNC was significantly associated with frequencies of MN (OR = 8.63, P<0.0001) and BN (OR = 5.62, P=0.001).
Our results suggest that increased chromosome/DNA instabilities may be associated with HNC.
American Psychological Association (APA)
Khlifi, Rim& Trabelsi-Ksibi, Fatma& Chakroun, Amine& Rebaï, Ahmed& Hamza-Chaffai, Amel. 2013. Cytogenetic Abnormality in Exfoliated Cells of Buccal Mucosa in Head and Neck Cancer Patients in the Tunisian Population: Impact of Different Exposure Sources. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1031068
Modern Language Association (MLA)
Khlifi, Rim…[et al.]. Cytogenetic Abnormality in Exfoliated Cells of Buccal Mucosa in Head and Neck Cancer Patients in the Tunisian Population: Impact of Different Exposure Sources. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1031068
American Medical Association (AMA)
Khlifi, Rim& Trabelsi-Ksibi, Fatma& Chakroun, Amine& Rebaï, Ahmed& Hamza-Chaffai, Amel. Cytogenetic Abnormality in Exfoliated Cells of Buccal Mucosa in Head and Neck Cancer Patients in the Tunisian Population: Impact of Different Exposure Sources. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1031068
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031068