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Sesame Oil Attenuates Ovalbumin-Induced Pulmonary Edema and Bronchial Neutrophilic Inflammation in Mice
Joint Authors
Hsu, Dur-Zong
Chu, Pei-Yi
Periasamy, Srinivasan
Liu, Ming-Yie
Liu, Chuan-Teng
Li, Ya-Hui
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Allergic asthma is one of the most common chronic inflammatory diseases of airways.
Severe asthma may lead to hospitalization and death.
Sesame oil is a natural product with anti-inflammatory property.
However, the effect of sesame oil on allergic asthma has never been studied.
Objective.
We investigate the effect of sesame oil on pulmonary inflammation in allergic asthma model.
Methods.
Allergic airway inflammation was induced by sensitizing with two doses of 10 mg ovalbumin (OVA) and then challenged with 1% OVA nebulizer exposure (1 h/day) for 3 days.
Sesame oil (0.25, 0.5, or 1 mL/kg/day) was given orally 30 min before each challenge.
Samples were collected 24 h after the last challenge.
Results.
Data showed that sesame oil inhibited pulmonary edema and decreased interleukin (IL)-1β and IL-6 levels in bronchoalveolar lavage fluid in OVA-treated mice.
Sesame oil also decreased pulmonary nitrite level, inducible nitric oxide synthase expression, and neutrophil infiltration induced by OVA.
Further, sesame oil decreased serum IgE level in OVA-treated mice.
Conclusion.
Sesame oil may attenuate pulmonary edema and bronchial neutrophilic inflammation by inhibiting systemic IgE level in allergic asthma.
American Psychological Association (APA)
Hsu, Dur-Zong& Liu, Chuan-Teng& Chu, Pei-Yi& Li, Ya-Hui& Periasamy, Srinivasan& Liu, Ming-Yie. 2013. Sesame Oil Attenuates Ovalbumin-Induced Pulmonary Edema and Bronchial Neutrophilic Inflammation in Mice. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031070
Modern Language Association (MLA)
Hsu, Dur-Zong…[et al.]. Sesame Oil Attenuates Ovalbumin-Induced Pulmonary Edema and Bronchial Neutrophilic Inflammation in Mice. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1031070
American Medical Association (AMA)
Hsu, Dur-Zong& Liu, Chuan-Teng& Chu, Pei-Yi& Li, Ya-Hui& Periasamy, Srinivasan& Liu, Ming-Yie. Sesame Oil Attenuates Ovalbumin-Induced Pulmonary Edema and Bronchial Neutrophilic Inflammation in Mice. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031070
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031070