Oxidative Stress and Antimicrobial Activity of Chromium(III) and Ruthenium(II) Complexes on Staphylococcus aureus and Escherichia coli
Joint Authors
Páez, Paulina L.
Becerra, María C.
Albesa, Inés
Bazán, Claudia M.
Bongiovanni, María E.
Toneatto, Judith
Argüello, Gerardo A.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The prevalence of antibiotic resistance has resulted in the need for new approaches to be developed to combat previously easily treatable infections.
The main aim of this work was to establish the potential of the synthetic α-diimine chromium(III) and ruthenium(II) complexes (where the α-diimine ligands are bpy = 2,2-bipyridine, phen = 1,10-phenanthroline, and dppz = dipyrido[3,2-a:2′,3′-c]-phenazine) like [Cr(phen)3]3+, [Cr(phen)2(dppz)]3+, [Ru(phen)3]2+, and [Ru(bpy)3]2+ as antibacterial agents by generating oxidative stress.
The [Cr(phen)3]3+ and [Cr(phen)2(dppz)]3+ complexes showed activity against Gram positive and Gram negative bacteria with minimum inhibitory concentrations (MICs) ranging from 0.125 μg/mL to 1 μg/mL, while [Ru(phen)3]2+ and [Ru(bpy)3]2+ do not exhibit antimicrobial activity against the two bacterial genera studied at the concentration range used.
When ciprofloxacin was combined with [Cr(phen)3]3+ for the inhibition of Staphylococcus aureus and Escherichia coli, an important synergistic effect was observed, FIC 0.066 for S.
aureus and FIC 0.064 for E.
coli.
The work described here shows that chromium(III) complexes are bactericidal for S.
aureus and E.
coli.
Our results indicate that α-diimine chromium(III) complexes may be interesting to open new paths for metallodrug chemotherapy against different bacterial genera since some of these complexes have been found to exhibit remarkable antibacterial activities.
American Psychological Association (APA)
Páez, Paulina L.& Bazán, Claudia M.& Bongiovanni, María E.& Toneatto, Judith& Albesa, Inés& Becerra, María C.…[et al.]. 2013. Oxidative Stress and Antimicrobial Activity of Chromium(III) and Ruthenium(II) Complexes on Staphylococcus aureus and Escherichia coli. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031072
Modern Language Association (MLA)
Páez, Paulina L.…[et al.]. Oxidative Stress and Antimicrobial Activity of Chromium(III) and Ruthenium(II) Complexes on Staphylococcus aureus and Escherichia coli. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1031072
American Medical Association (AMA)
Páez, Paulina L.& Bazán, Claudia M.& Bongiovanni, María E.& Toneatto, Judith& Albesa, Inés& Becerra, María C.…[et al.]. Oxidative Stress and Antimicrobial Activity of Chromium(III) and Ruthenium(II) Complexes on Staphylococcus aureus and Escherichia coli. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031072
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031072