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Metabolism, Physiological Role, and Clinical Implications of Sphingolipids in Gastrointestinal Tract
Joint Authors
Łukaszuk, Bartłomiej
Wiesiołek, Patrycja
Kurek, Krzysztof
Chabowski, Adrian
Żendzian-Piotrowska, Małgorzata
Piotrowska, Dominika M.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Sphingolipids in digestive system are responsible for numerous important physiological and pathological processes.
In the membrane of gut epithelial cells, sphingolipids provide structural integrity, regulate absorption of some nutrients, and act as receptors for many microbial antigens and their toxins.
Moreover, bioactive sphingolipids such as ceramide or sphingosine-1-phosphate regulate cellular growth, differentiation, and programmed cell death—apoptosis.
Although it is well established that sphingolipids have clinical implications in gastrointestinal tumorigenesis or inflammation, further studies are needed to fully explore the role of sphingolipids in neoplastic and inflammatory diseases in gastrointestinal tract.
Pharmacological agents which regulate metabolism of sphingolipids can be potentially used in the management of colorectal cancer or inflammatory bowel diseases.
The aim of this work is to critically the review physiological and pathological roles of sphingolipids in the gastrointestinal tract.
American Psychological Association (APA)
Kurek, Krzysztof& Łukaszuk, Bartłomiej& Piotrowska, Dominika M.& Wiesiołek, Patrycja& Chabowski, Adrian& Żendzian-Piotrowska, Małgorzata. 2013. Metabolism, Physiological Role, and Clinical Implications of Sphingolipids in Gastrointestinal Tract. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1031074
Modern Language Association (MLA)
Kurek, Krzysztof…[et al.]. Metabolism, Physiological Role, and Clinical Implications of Sphingolipids in Gastrointestinal Tract. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1031074
American Medical Association (AMA)
Kurek, Krzysztof& Łukaszuk, Bartłomiej& Piotrowska, Dominika M.& Wiesiołek, Patrycja& Chabowski, Adrian& Żendzian-Piotrowska, Małgorzata. Metabolism, Physiological Role, and Clinical Implications of Sphingolipids in Gastrointestinal Tract. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1031074
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031074