Factors Affecting Graft Survival among Patients Receiving Kidneys from Live Donors: A Single-Center Experience
Joint Authors
Ghoneim, Mohamed A.
Bakr, Mohamed A.
Akl, Ahmed I.
Shokeir, Ahmed A.
Shehab El-Dein, Ahmed B.
Ammar, Hesham M.
Sheashaa, Hussein A.
El-Baz, Mahmoud A.
Ismail, Amani M.
Refaie, Ayman F.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Introduction.
The aim of this report is to study the graft and patient survival in a large cohort of recipients with an analysis of factors that may affect the final outcomes.
Methods.
Between March 1976 and March 2008, 1967 consecutive live-donor renal transplants were carried out.
Various variables that may have an impact on patients and/or graft survival were studied in two steps.
Initially, a univariate analysis was carried out.
Thereafter, significant variables were embedded in a stepwise regression analysis.
Results.
The overall graft survival was 86.7% and 65.5%, at 5 and 10 years, respectively.
The projected half-life for grafts was 17.5 years and for patients was 22 years.
Five factors had an independent negative impact on graft survival: donor's age, genetic considerations, the type of primary immunosuppression, number of acute rejection episodes, and total steroid dose during the first 3 months after transplantation.
Conclusions.
Despite refinements in tissue matching techniques and improvements in immunosuppression protocols, an important proportion of grafts is still lost following living donor kidney transplantation, presumably due to chronic allograft nephropathy.
American Psychological Association (APA)
Ghoneim, Mohamed A.& Bakr, Mohamed A.& Refaie, Ayman F.& Akl, Ahmed I.& Shokeir, Ahmed A.& Shehab El-Dein, Ahmed B.…[et al.]. 2013. Factors Affecting Graft Survival among Patients Receiving Kidneys from Live Donors: A Single-Center Experience. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1031077
Modern Language Association (MLA)
Ghoneim, Mohamed A.…[et al.]. Factors Affecting Graft Survival among Patients Receiving Kidneys from Live Donors: A Single-Center Experience. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1031077
American Medical Association (AMA)
Ghoneim, Mohamed A.& Bakr, Mohamed A.& Refaie, Ayman F.& Akl, Ahmed I.& Shokeir, Ahmed A.& Shehab El-Dein, Ahmed B.…[et al.]. Factors Affecting Graft Survival among Patients Receiving Kidneys from Live Donors: A Single-Center Experience. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1031077
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031077