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Comparative Plasma Exposure of Albendazole after Administration of Rapidly Disintegrating Tablets in Dogs
Joint Authors
Lanusse, Carlos E.
Castro, Silvina G.
Dib, Alicia
Suarez, Gonzalo
Allemandi, Daniel
Sanchez Bruni, Sergio
Palma, Santiago D.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The main objectives of this study were (a) to evaluate the in vitro performance of the rapid disintegration tablets as a way to improve the solid dispersions and (b) to study the in vivo pharmacokinetics of the albendazole modified formulation in dogs.
Rapid disintegration of tablets seems to be a key factor for efficiency of solid dispersions with regard to improvement of the albendazole bioavailability.
The in vivo assays performed on dogs showed a marked increase in drug plasma exposure when albendazole was given in solid dispersions incorporated into rapid disintegration tablets compared with conventional solid dosage form.
American Psychological Association (APA)
Castro, Silvina G.& Dib, Alicia& Suarez, Gonzalo& Allemandi, Daniel& Lanusse, Carlos E.& Sanchez Bruni, Sergio…[et al.]. 2013. Comparative Plasma Exposure of Albendazole after Administration of Rapidly Disintegrating Tablets in Dogs. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031096
Modern Language Association (MLA)
Castro, Silvina G.…[et al.]. Comparative Plasma Exposure of Albendazole after Administration of Rapidly Disintegrating Tablets in Dogs. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1031096
American Medical Association (AMA)
Castro, Silvina G.& Dib, Alicia& Suarez, Gonzalo& Allemandi, Daniel& Lanusse, Carlos E.& Sanchez Bruni, Sergio…[et al.]. Comparative Plasma Exposure of Albendazole after Administration of Rapidly Disintegrating Tablets in Dogs. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031096
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031096