Antituberculosis: Synthesis and Antimycobacterial Activity of Novel Benzimidazole Derivatives
Joint Authors
Keng Yoon, Yeong
Ashraf Ali, Mohamed
Choon, Tan Soo
Ismail, Rusli
Chee Wei, Ang
Suresh Kumar, Raju
Beevi, Farzana
Osman, Hasnah
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A total of seven novel benzimidazoles were synthesized by a 4-step reaction starting from 4-fluoro-3-nitrobenzoic acid under relatively mild reaction conditions.
The synthesized compounds were screened for their antimycobacterial activity against M.
tuberculosis H37Rv (MTB-H37Rv) and INH-resistant M.
tuberculosis (INHR-MTB) strains using agar dilution method.
Three of them displayed good activity with MIC of less than 0.2 μM.
Compound ethyl 1-(2-(4-(4-(ethoxycarbonyl)-2-aminophenyl)piperazin-1-yl)ethyl)-2-(4-(5-(4-fluorophenyl)pyridin-3-ylphenyl-1H-benzo[d]imidazole-5-carboxylate (5g) was found to be the most active with MIC of 0.112 μM against MTB-H37Rv and 6.12 μM against INHR-MTB, respectively.
American Psychological Association (APA)
Keng Yoon, Yeong& Ashraf Ali, Mohamed& Choon, Tan Soo& Ismail, Rusli& Chee Wei, Ang& Suresh Kumar, Raju…[et al.]. 2013. Antituberculosis: Synthesis and Antimycobacterial Activity of Novel Benzimidazole Derivatives. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031103
Modern Language Association (MLA)
Keng Yoon, Yeong…[et al.]. Antituberculosis: Synthesis and Antimycobacterial Activity of Novel Benzimidazole Derivatives. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1031103
American Medical Association (AMA)
Keng Yoon, Yeong& Ashraf Ali, Mohamed& Choon, Tan Soo& Ismail, Rusli& Chee Wei, Ang& Suresh Kumar, Raju…[et al.]. Antituberculosis: Synthesis and Antimycobacterial Activity of Novel Benzimidazole Derivatives. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031103
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031103
