2-Heptyl-Formononetin Increases Cholesterol and Induces Hepatic Steatosis in Mice
Joint Authors
Hansen, A. K.
Andersen, Charlotte
Schjoldager, Janne G.
Tortzen, Christian G.
Vegge, Andreas
Hufeldt, Majbritt R.
Skaanild, Mette T.
Vogensen, Finn K.
Kristiansen, Karsten
Nielsen, John
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-29
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Consumption of isoflavones may prevent adiposity, hepatic steatosis, and dyslipidaemia.
However, studies in the area are few and primarily with genistein.
This study investigated the effects of formononetin and its synthetic analogue, 2-heptyl-formononetin (C7F), on lipid and cholesterolmetabolism in C57BL/6J mice.
The mice were fed a cholesterol-enriched diet for five weeks to induce hypercholesterolemia and were then fed either the cholesterol-enriched diet or the cholesterol-enriched diet-supplemented formononetin or C7F for three weeks.
Body weight and composition, glucose homeostasis, and plasma lipids were compared.
In another experiment, micewere fed the above diets for five weeks, and hepatic triglyceride accumulation and gene expression and histology of adipose tissue and liver were examined.
Supplementation with C7F increased plasma HDL-cholesterol thereby increasing the plasma level of total cholesterol.
Supplementation with formononetin did not affect plasma cholesterol but increased plasma triglycerides levels.
Supplementation with formononetin and C7F induced hepatic steatosis.
However, formononetin decreased markers of inflammation and liver injury.
The development of hepatic steatosis was associated with deregulated expression of hepatic genes involved in lipid and lipoprotein metabolism.
In conclusion, supplementation with formononetin and C7F to a cholesterol-enriched diet adversely affected lipid and lipoprotein metabolism in C57BL/6J mice.
American Psychological Association (APA)
Andersen, Charlotte& Schjoldager, Janne G.& Tortzen, Christian G.& Vegge, Andreas& Hufeldt, Majbritt R.& Skaanild, Mette T.…[et al.]. 2013. 2-Heptyl-Formononetin Increases Cholesterol and Induces Hepatic Steatosis in Mice. BioMed Research International،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1031104
Modern Language Association (MLA)
Andersen, Charlotte…[et al.]. 2-Heptyl-Formononetin Increases Cholesterol and Induces Hepatic Steatosis in Mice. BioMed Research International No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-1031104
American Medical Association (AMA)
Andersen, Charlotte& Schjoldager, Janne G.& Tortzen, Christian G.& Vegge, Andreas& Hufeldt, Majbritt R.& Skaanild, Mette T.…[et al.]. 2-Heptyl-Formononetin Increases Cholesterol and Induces Hepatic Steatosis in Mice. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1031104
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031104