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Photo-Induced Antitumor Effect of 3,6-Bis(1-methyl-4-vinylpyridinium) Carbazole Diiodide
Joint Authors
Chou, Ya-Shuan
Chang, Cheng-Chung
Chang, Ta-Chau
Young, Tai-Horng
Lou, Pei-Jen
Yang, Tsung-Lin
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We have applied a fluorescent molecule 3,6-bis(1-methyl-4-vinylpyridinium) carbazole diiodide (BMVC) for tumor targeting and treatment.
In this study, we investigated the photo-induced antitumor effect of BMVC.
In vitro cell line studies showed that BMVC significantly killed TC-1 tumor cells at light dose greater than 40 J/cm2.
The fluorescence of BMVC in the tumor peaked at 3 hours and then gradually decreased to reach the control level after 24 hours.
In vivo tumor treatment studies showed BMVC plus light irradiation (iPDT) significantly inhibited the tumor growth.
At day 24 after tumor implantation, tumor volume was measured to be 225±79 mm3, 2542±181 mm3, 1533±766 mm3, and 1317±108 mm3 in the iPDT, control, light-only, and BMVC-only groups, respectively.
Immunohistochemistry studies showed the microvascular density was significantly lower in the iPDT group.
Taken together, our results demonstrated that BMVC may be a potent tumor-specific photosensitizer (PS) for PDT.
American Psychological Association (APA)
Chou, Ya-Shuan& Chang, Cheng-Chung& Chang, Ta-Chau& Yang, Tsung-Lin& Young, Tai-Horng& Lou, Pei-Jen. 2012. Photo-Induced Antitumor Effect of 3,6-Bis(1-methyl-4-vinylpyridinium) Carbazole Diiodide. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1031111
Modern Language Association (MLA)
Chou, Ya-Shuan…[et al.]. Photo-Induced Antitumor Effect of 3,6-Bis(1-methyl-4-vinylpyridinium) Carbazole Diiodide. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1031111
American Medical Association (AMA)
Chou, Ya-Shuan& Chang, Cheng-Chung& Chang, Ta-Chau& Yang, Tsung-Lin& Young, Tai-Horng& Lou, Pei-Jen. Photo-Induced Antitumor Effect of 3,6-Bis(1-methyl-4-vinylpyridinium) Carbazole Diiodide. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1031111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031111