An Immunocytochemical Study of Interchromatin Granule Clusters in Early Mouse Embryos
Joint Authors
Bogolyubov, Dmitry S.
Bogolyubova, Irina O.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Interchromatin granule clusters (IGCs) are universal nuclear domains.
Their molecular composition and functions were studied in detail in somatic cells.
Here, we studied IGCs in the nuclei of early mouse embryos during zygotic gene activation (ZGA).
We found that the size of IGCs gradually increases during realization of ZGA events.
Using immunocytochemical approaches, we showed that the molecular composition of IGCs is also modified in mouse embryos.
The hyperphosphorylated form of RNA polymerase II and the transcription factor TFIID have been revealed in IGCs before the end of ZGA.
Association of these factors with IGCs became more noticeable during ZGA realization.
Our data suggest that IGCs in early mouse embryos have some functional peculiarities connected most probably with IGC formation de novo.
We believe that IGCs in early mouse embryos not only are storage sites of splicing factors but also may be involved in mRNA metabolism and represent the multifunctional nuclear domains.
American Psychological Association (APA)
Bogolyubova, Irina O.& Bogolyubov, Dmitry S.. 2013. An Immunocytochemical Study of Interchromatin Granule Clusters in Early Mouse Embryos. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1031115
Modern Language Association (MLA)
Bogolyubova, Irina O.& Bogolyubov, Dmitry S.. An Immunocytochemical Study of Interchromatin Granule Clusters in Early Mouse Embryos. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1031115
American Medical Association (AMA)
Bogolyubova, Irina O.& Bogolyubov, Dmitry S.. An Immunocytochemical Study of Interchromatin Granule Clusters in Early Mouse Embryos. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1031115
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031115