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In Vitro Antiophidian Mechanisms of Hypericum brasiliense Choisy Standardized Extract: Quercetin-Dependent Neuroprotection
Joint Authors
Dal Belo, Cháriston André
Rodrigues-Simioni, Lea
Lucho, Ana Paula de Bairros
Vinadé, Lúcia
Seibert França, Hildegardo
Rocha, Leandro
Marangoni, Sérgio
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The neuroprotection induced by Hypericum brasiliense Choisy extract (HBE) and its main active polyphenol compound quercetin, against Crotalus durissus terrificus (Cdt) venom and crotoxin and crotamine, was enquired at both central and peripheral mammal nervous system.
Cdt venom (10 μg/mL) or crotoxin (1 μg/mL) incubated at mouse phrenic nerve-diaphragm preparation (PND) induced an irreversible and complete neuromuscular blockade, respectively.
Crotamine (1 μg/mL) only induced an increase of muscle strength at PND preparations.
At mouse brain slices, Cdt venom (1, 5, and 10 μg/mL) decreased cell viability.
HBE (100 μg/mL) inhibited significantly the facilitatory action of crotamine (1 μg/mL) and was partially active against the neuromuscular blockade of crotoxin (1 μg/mL) (data not shown).
Quercetin (10 μg/mL) mimicked the neuromuscular protection of HBE (100 μg/mL), by inhibiting almost completely the neurotoxic effect induced by crotoxin (1 μg/mL) and crotamine (1 μg/mL).
HBE (100 μg/mL) and quercetin (10 μg/mL) also increased cell viability in mice brain slices.
Quercetin (10 μg/mL) was more effective than HBE (100 μg/mL) in counteracting the cell lysis induced by Cdt venom (1 and 10 μg/mL, resp.).
These results and a further phytochemical and toxicological investigations could open new perspectives towards therapeutic use of Hypericum brasiliense standardized extract and quercetin, especially to counteract the neurotoxic effect induced by snake neurotoxic venoms.
American Psychological Association (APA)
Dal Belo, Cháriston André& Lucho, Ana Paula de Bairros& Vinadé, Lúcia& Rocha, Leandro& Seibert França, Hildegardo& Marangoni, Sérgio…[et al.]. 2013. In Vitro Antiophidian Mechanisms of Hypericum brasiliense Choisy Standardized Extract: Quercetin-Dependent Neuroprotection. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031130
Modern Language Association (MLA)
Dal Belo, Cháriston André…[et al.]. In Vitro Antiophidian Mechanisms of Hypericum brasiliense Choisy Standardized Extract: Quercetin-Dependent Neuroprotection. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1031130
American Medical Association (AMA)
Dal Belo, Cháriston André& Lucho, Ana Paula de Bairros& Vinadé, Lúcia& Rocha, Leandro& Seibert França, Hildegardo& Marangoni, Sérgio…[et al.]. In Vitro Antiophidian Mechanisms of Hypericum brasiliense Choisy Standardized Extract: Quercetin-Dependent Neuroprotection. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031130
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031130