Role of Omega-3 Polyunsaturated Fatty Acids in the Production of Prostaglandin E2 and Nitric Oxide during Experimental Murine Paracoccidioidomycosis
Joint Authors
Visentainer, Jeane Eliete Laguila
Dalalio, Márcia Machado de Oliveira
Sargi, S. C.
Moraes, A. G.
Morais, D. R.
Visentainer, J. V.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
There has recently been increased interest in the potential health effects of omega-3 polyunsaturated fatty acids on the immune system.
Paracoccidioidomycosis is the most important endemic mycosis in Latin America.
Macrophages have a fundamental role and act as first line of organism defense.
The purpose of this study was to analyze the effect of n-3 fatty acids on the production of PGE2 and NO by mice infected with Pb18 and fed a diet enriched with LNA for 8 weeks.
To study the effect of omega-3 fatty acids on macrophage activity during experimental paracoccidioidomycosis, mice were infected with Pb18 and fed a diet supplemented with LNA.
PGE2 in the serum of animals was analyzed and NO in the supernatants of macrophages cultured and challenged in vitro with Pb18 was measured.
Omega-3 fatty acids seemed to decrease the production of PGE2 in vivo in the infected group fed an LNA-supplemented diet during the 4th and 8th weeks of the experiment.
At the same time, we observed an increase in synthesis of NO by peritoneal macrophages in this group.
Omega-3 fatty acids thus appear to have an immunomodulatory effect in paracoccidioidomycosis.
American Psychological Association (APA)
Sargi, S. C.& Dalalio, Márcia Machado de Oliveira& Moraes, A. G.& Visentainer, Jeane Eliete Laguila& Morais, D. R.& Visentainer, J. V.. 2013. Role of Omega-3 Polyunsaturated Fatty Acids in the Production of Prostaglandin E2 and Nitric Oxide during Experimental Murine Paracoccidioidomycosis. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031136
Modern Language Association (MLA)
Sargi, S. C.…[et al.]. Role of Omega-3 Polyunsaturated Fatty Acids in the Production of Prostaglandin E2 and Nitric Oxide during Experimental Murine Paracoccidioidomycosis. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1031136
American Medical Association (AMA)
Sargi, S. C.& Dalalio, Márcia Machado de Oliveira& Moraes, A. G.& Visentainer, Jeane Eliete Laguila& Morais, D. R.& Visentainer, J. V.. Role of Omega-3 Polyunsaturated Fatty Acids in the Production of Prostaglandin E2 and Nitric Oxide during Experimental Murine Paracoccidioidomycosis. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031136
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031136