Effects of Nigella sativa and Lepidium sativum on Cyclosporine Pharmacokinetics
Joint Authors
Alkharfy, Khalid M.
Korashy, Hesham M.
Al-Jenoobi, F. I.
Al-Suwayeh, S. A.
Muzaffar, Iqbal
Alam, Mohd Aftab
Al-Mohizea, Abdullah M.
Ahad, Abdul
Raish, Mohd
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The present study was conducted to investigate the effects of Nigella sativa and Lepidium sativum on the pharmacokinetics of cyclosporine in rabbits.
Two groups of animals were treated separately with Nigella sativa (200 mg/kg p.o.) or Lepidium sativum (150 mg/kg p.o.) for eight consecutive days.
On the 8th day, cyclosporine (30 mg/kg p.o.) was administered to each group one hour after herbal treatment.
Blood samples were withdrawn at different time intervals (0.0, 0.5, 1.0, 1.5, 2.0, 3.0, 4.0, 6.0, 8.0, 12, and 24 hrs) from marginal ear vein.
Cyclosporine was analyzed using UPLC/MS method.
The coadministration of Nigella sativa significantly decreased the Cmax and AUC0-∞ of cyclosporine; the change was observed by 35.5% and 55.9%, respectively (P≤0.05).
Lepidium sativum did not produce any significant change in Cmax of cyclosporine, although its absorption was significantly delayed compared with control group.
A remarkable change was observed in Tmax and AUC0-t of Lepidium sativum treated group.
Our findings suggest that concurrent consumption of Nigella sativa and Lepidium sativum could alter the pharmacokinetics of cyclosporine at various levels.
American Psychological Association (APA)
Al-Jenoobi, F. I.& Al-Suwayeh, S. A.& Muzaffar, Iqbal& Alam, Mohd Aftab& Alkharfy, Khalid M.& Korashy, Hesham M.…[et al.]. 2013. Effects of Nigella sativa and Lepidium sativum on Cyclosporine Pharmacokinetics. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031140
Modern Language Association (MLA)
Al-Jenoobi, F. I.…[et al.]. Effects of Nigella sativa and Lepidium sativum on Cyclosporine Pharmacokinetics. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1031140
American Medical Association (AMA)
Al-Jenoobi, F. I.& Al-Suwayeh, S. A.& Muzaffar, Iqbal& Alam, Mohd Aftab& Alkharfy, Khalid M.& Korashy, Hesham M.…[et al.]. Effects of Nigella sativa and Lepidium sativum on Cyclosporine Pharmacokinetics. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031140
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031140