Microtubule-Associated Proteins in Mesial Temporal Lobe Epilepsy with and without Psychiatric Comorbidities and Their Relation with Granular Cell Layer Dispersion
Joint Authors
Kandratavicius, Ludmyla
Monteiro, Mariana Raquel
Assirati, Joao Alberto
Leite, João P.
Carlotti Jr., C. G.
Cecílio Hallak, J. E.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Despite strong association between epilepsy and psychiatric comorbidities, biological substrates are unknown.
We have previously reported decreased mossy fiber sprouting in mesial temporal lobe epilepsy (MTLE) patients with psychosis and increased in those with major depression.
Microtubule associated proteins (MAPs) are essentially involved in dendritic and synaptic sprouting.
Methods.
MTLE hippocampi of subjects without psychiatric history, MTLE + major depression, and MTLE + interictal psychosis derived from epilepsy surgery and control necropsies were investigated for neuronal density, granular layer dispersion, and MAP2 and tau immunohistochemistry.
Results.
Altered MAP2 and tau expression in MTLE and decreased tau expression in MTLE with psychosis were found.
Granular layer dispersion correlated inversely with verbal memory scores, and with MAP2 and tau expression in the entorhinal cortex.
Patients taking fluoxetine showed increased neuronal density in the granular layer and those taking haloperidol decreased neuronal density in CA3 and subiculum.
Conclusions.
Our results indicate relations between MAPs, granular layer dispersion, and memory that have not been previously investigated.
Differential MAPs expression in human MTLE hippocampi with and without psychiatric comorbidities suggests that psychopathological states in MTLE rely on differential morphological and possibly neurochemical backgrounds.
This clinical study was approved by our institution’s Research Ethics Board (HC-FMRP no.
1270/2008) and is registered under the Brazilian National System of Information on Ethics in Human Research (SISNEP) no.
0423.0.004.000-07.
American Psychological Association (APA)
Kandratavicius, Ludmyla& Monteiro, Mariana Raquel& Cecílio Hallak, J. E.& Carlotti Jr., C. G.& Assirati, Joao Alberto& Leite, João P.. 2013. Microtubule-Associated Proteins in Mesial Temporal Lobe Epilepsy with and without Psychiatric Comorbidities and Their Relation with Granular Cell Layer Dispersion. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1031147
Modern Language Association (MLA)
Kandratavicius, Ludmyla…[et al.]. Microtubule-Associated Proteins in Mesial Temporal Lobe Epilepsy with and without Psychiatric Comorbidities and Their Relation with Granular Cell Layer Dispersion. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1031147
American Medical Association (AMA)
Kandratavicius, Ludmyla& Monteiro, Mariana Raquel& Cecílio Hallak, J. E.& Carlotti Jr., C. G.& Assirati, Joao Alberto& Leite, João P.. Microtubule-Associated Proteins in Mesial Temporal Lobe Epilepsy with and without Psychiatric Comorbidities and Their Relation with Granular Cell Layer Dispersion. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1031147
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031147