Helminth ExcretedSecreted Antigens Repress Expression of LPS-Induced Let-7i but Not miR-146a and miR-155 in Human Dendritic Cells
Joint Authors
Ledesma-Soto, Yadira
Pérez-Miranda, Magaly
Mejía-Domínguez, Ana M.
Sanchez-Muñoz, Fausto
Gómez-García, Lorena
Bojalil, Rafael
Terrazas, Luis I.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
MicroRNAs have emerged as key regulators of immune responses.
They influence immune cells' function and probably the outcome of several infections.
Currently, it is largely unknown if helminth parasites and their antigens modify host microRNAs expression.
The aim of this study was to explore if excreted/secreted antigens of Taenia crassiceps regulate LPS-induced miRNAs expression in human Dendritic Cells.
We found that these antigens repressed LPS-let-7i induction but not mir-146a or mir-155 and this correlates with a diminished inflammatory response.
This let-7i downregulation in Dendritic Cells constitutes a novel feature of the modulatory activity that helminth-derived antigens exert on their host.
American Psychological Association (APA)
Terrazas, Luis I.& Sanchez-Muñoz, Fausto& Pérez-Miranda, Magaly& Mejía-Domínguez, Ana M.& Ledesma-Soto, Yadira& Bojalil, Rafael…[et al.]. 2012. Helminth ExcretedSecreted Antigens Repress Expression of LPS-Induced Let-7i but Not miR-146a and miR-155 in Human Dendritic Cells. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031158
Modern Language Association (MLA)
Terrazas, Luis I.…[et al.]. Helminth ExcretedSecreted Antigens Repress Expression of LPS-Induced Let-7i but Not miR-146a and miR-155 in Human Dendritic Cells. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1031158
American Medical Association (AMA)
Terrazas, Luis I.& Sanchez-Muñoz, Fausto& Pérez-Miranda, Magaly& Mejía-Domínguez, Ana M.& Ledesma-Soto, Yadira& Bojalil, Rafael…[et al.]. Helminth ExcretedSecreted Antigens Repress Expression of LPS-Induced Let-7i but Not miR-146a and miR-155 in Human Dendritic Cells. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031158
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031158