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Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy
Joint Authors
Basta-Jovanovic, Gordana
Radojevic, Sanja
Pavlovic, Jelena
Dopsaj, Violeta
Naumovic, Radomir
Simic-Ogrizovic, Sanja
Bojic, Suzana
Kotur-Stevuljevic, Jelena
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
Retrospective study was designed to examine the importance of tissue kidney injury molecule-1 (KIM-1) expression in predicting kidney function in sixty patients (27 males) aged 34.15 ± 12.23 years with different kidney diseases over three years after kidney biopsy.
Materials and Methods.
Tissue KIM-1 expression was determined immunohistochemically and KIM-1 staining was scored semiquantitatively, as well as tubulointerstitialis (TIN), inflammation, atrophy, and fibrosis.
Kidney function (MDRD formula) and proteinuria/day were evaluated at the time of biopsy (GFR0) and 6, 12, 24, and 36 months later.
Results.
Significantly positive correlations between tissue KIM-1 expression and age (r=0.313), TIN inflammation (r=0.456), fibrosis (r=0.317), and proteinuria at 6 months (r=0.394) as well as negative correlations with GFR0 (r=−0.572), GFR6 (r=−0.442), GFR24 (r=−0.398), and GFR36 (r=−0.412) were found.
Meanwhile, TIN inflammation was the best predictor of all measured kidney functions during three years, while tissue KIM-1 expression (P=0.016) was a predictor only at 6 months after biopsy.
Conclusion.
Tissue KIM-1 expression significantly predicts kidney function solely at 6 months after biopsy, when the effects of immune and nonimmune treatments are the strongest.
American Psychological Association (APA)
Simic-Ogrizovic, Sanja& Bojic, Suzana& Basta-Jovanovic, Gordana& Radojevic, Sanja& Pavlovic, Jelena& Kotur-Stevuljevic, Jelena…[et al.]. 2013. Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy. Disease Markers،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031187
Modern Language Association (MLA)
Simic-Ogrizovic, Sanja…[et al.]. Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy. Disease Markers No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1031187
American Medical Association (AMA)
Simic-Ogrizovic, Sanja& Bojic, Suzana& Basta-Jovanovic, Gordana& Radojevic, Sanja& Pavlovic, Jelena& Kotur-Stevuljevic, Jelena…[et al.]. Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031187
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031187