Positive Association between GCKR rs780093 Polymorphism and Coronary Heart Disease in the Aged Han Chinese
Joint Authors
Huang, Xiaoyan
Guo, Jian
Chen, Zhikui
Jiang, Qingjun
Ba, Yanna
Zhou, Jianqing
Yang, Xi
Ye, Huadan
Lian, Jiangfang
Duan, Shiwei
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
Previous studies have confirmed that GCKR rs780093 polymorphism is associated with triglyceride (TG), a known risk factor of coronary heart disease (CHD).
The goal of our study is to explore the association of GCKR rs780093 polymorphism with CHD in Han Chinese population.
Methods and Results.
A total of 568 CHD cases and 494 non-CHD controls were enrolled in the current case-control study.
Genotyping was done using melting temperature shift (Tm-shift) approach.
Our results also showed that GCKR rs780093 polymorphism was significantly associated with TG level (P=0.0016).
Although there was no significant association between cases and controls (P>0.05), a breakdown analysis by age yielded a significant association of GCKR rs780093 polymorphism with CHD in individuals aged 65 and older (genotype: χ2=6.86; df = 2; P=0.03; allele: χ2=4.11; df = 1; P=0.04).
Conclusion.
Our findings confirmed the contribution of GCKR rs780093 polymorphism to TG metabolism and demonstrated GCKR rs780093 as a risk factor of CHD in individuals aged 65 and older.
American Psychological Association (APA)
Lian, Jiangfang& Guo, Jian& Chen, Zhikui& Jiang, Qingjun& Ye, Huadan& Huang, Xiaoyan…[et al.]. 2013. Positive Association between GCKR rs780093 Polymorphism and Coronary Heart Disease in the Aged Han Chinese. Disease Markers،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031189
Modern Language Association (MLA)
Lian, Jiangfang…[et al.]. Positive Association between GCKR rs780093 Polymorphism and Coronary Heart Disease in the Aged Han Chinese. Disease Markers No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1031189
American Medical Association (AMA)
Lian, Jiangfang& Guo, Jian& Chen, Zhikui& Jiang, Qingjun& Ye, Huadan& Huang, Xiaoyan…[et al.]. Positive Association between GCKR rs780093 Polymorphism and Coronary Heart Disease in the Aged Han Chinese. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031189
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031189