Role of SH Levels and Markers of Immune Response in the Stroke
Joint Authors
Musumeci, Salvatore
Persichilli, Silvia
Angeletti, Silvia
Sotgiu, Stefano
Arru, Giannina
Fois, Maria Laura
Minucci, Angelo
Musumeci, Maria
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Sulfhydryl groups (SH) are considered a key factor in redox sensitive reaction of plasma, and their modification could be considered an expression of abnormal generation of oxygen free radicals.
Methods.
Fifty consecutive patients with acute brain stroke were enclosed in this study.
The plasma concentrations of SH groups were correlated to cytokines (IL-1b, IL-6, IL-8, TNF-α), plasma chitotriosidase (Chit), metalloprotease (MMP2–9), intercellular adhesion molecule-1 (ICAM-1).
Results.
The results demonstrated a significant reduction of SH groups within 24 hours from the onset of an acute ischemic stroke, a reduction of plasma IL-1b, IL-6, and IL-8, and an increase of Chit and TNF-α in relation to the stroke severity.
Conclusion.
The observation of an intense microenvironment activation that follows the stroke and the correlation between SH levels and markers of immune response suggest that, especially in stroke, is necessary to maintain the redox function to prevent the brain damage.
The reduced SH levels represent an attempt to neutralize the abnormal generation of free radicals.
Since the reperfusion of brain after ischemic event represents a severe oxidative stress, which must be corrected by regeneration of redox sensitive function, pharmacological intervention could be beneficial in this setting.
American Psychological Association (APA)
Musumeci, Maria& Sotgiu, Stefano& Persichilli, Silvia& Arru, Giannina& Angeletti, Silvia& Fois, Maria Laura…[et al.]. 2013. Role of SH Levels and Markers of Immune Response in the Stroke. Disease Markers،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031191
Modern Language Association (MLA)
Musumeci, Maria…[et al.]. Role of SH Levels and Markers of Immune Response in the Stroke. Disease Markers No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1031191
American Medical Association (AMA)
Musumeci, Maria& Sotgiu, Stefano& Persichilli, Silvia& Arru, Giannina& Angeletti, Silvia& Fois, Maria Laura…[et al.]. Role of SH Levels and Markers of Immune Response in the Stroke. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031191
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031191