![](/images/graphics-bg.png)
Assessment of Endothelial Dysfunction: The Role of Symmetrical Dimethylarginine and Proinflammatory Markers in Chronic Kidney Disease and Renal Transplant Recipients
Joint Authors
Jelic-Ivanovic, Zorana
Bogavac-Stanojevic, Natasa
Spasojevic-Kalimanovska, Vesna
Giga, Vojislav
Dopsaj, Violeta
Spasic, Slavica
Simic-Ogrizovic, Sanja
Kotur-Stevuljevic, Jelena
Memon, Lidija
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
The study was designed to evaluate associations between symmetric dimethylarginine (SDMA), inflammation, and superoxide anion (O2∙-) with endothelial function and to determine their potential for screening of endothelial dysfunction in patients with chronic kidney disease (CKD) and renal transplant (RT) recipients.
Materials and Methods.
We included 64 CKD and 52 RT patients.
Patients were stratified according to brachial artery flow-mediated dilation (FMD).
Results.
Logistic regression analysis showed that high SDMA and high sensitive C-reactive protein (hs-CRP) were associated with impaired FMD in CKD and RT patients, after adjustment for glomerular filtration rate.
The ability of inflammation, SDMA, and O2∙- to detect impaired FMD was investigated by receiving operative characteristic analysis.
Hs-CRP (area under the curves (AUC) = 0.754, P<0.001), IL-6 (AUC = 0.699, P=0.002), and SDMA (AUC = 0.689, P=0.007) had the highest ability to detect impaired FMD.
SDMA in combination with inflammatory parameters and/or O2∙- had better screening performance than SDMA alone.
Conclusions.
Our results indicate a strong predictable association between hs-CRP, SDMA, and endothelial dysfunction in CKD patients and RT recipients.
The individual marker that showed the strongest discriminative ability for endothelial dysfunction is hs-CRP, but its usefulness as a discriminatory marker for efficient diagnosis of endothelial dysfunction should be examined in prospective studies.
American Psychological Association (APA)
Memon, Lidija& Spasojevic-Kalimanovska, Vesna& Bogavac-Stanojevic, Natasa& Kotur-Stevuljevic, Jelena& Simic-Ogrizovic, Sanja& Giga, Vojislav…[et al.]. 2013. Assessment of Endothelial Dysfunction: The Role of Symmetrical Dimethylarginine and Proinflammatory Markers in Chronic Kidney Disease and Renal Transplant Recipients. Disease Markers،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1031194
Modern Language Association (MLA)
Memon, Lidija…[et al.]. Assessment of Endothelial Dysfunction: The Role of Symmetrical Dimethylarginine and Proinflammatory Markers in Chronic Kidney Disease and Renal Transplant Recipients. Disease Markers No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1031194
American Medical Association (AMA)
Memon, Lidija& Spasojevic-Kalimanovska, Vesna& Bogavac-Stanojevic, Natasa& Kotur-Stevuljevic, Jelena& Simic-Ogrizovic, Sanja& Giga, Vojislav…[et al.]. Assessment of Endothelial Dysfunction: The Role of Symmetrical Dimethylarginine and Proinflammatory Markers in Chronic Kidney Disease and Renal Transplant Recipients. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1031194
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031194