Multivariate Path Analysis of Serum 25-Hydroxyvitamin D Concentration, Inflammation, and Risk of Type 2 Diabetes Mellitus
Joint Authors
Kabadi, Shaum M.
Zakeri, Issa F.
Auchincloss, Amy H.
Liu, Longjian
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Aims.
Despite growing interest in the protective role that vitamin D may have in health outcomes, little research has examined the mechanisms underlying this role.
This study aimed to test two hypotheses: (1) serum 25-hydroxyvitamin D [25(OH)D] is inversely associated with type 2 diabetes mellitus (T2DM) and elevated hemoglobin A1c; (2) these associations are mediated by serum C-reactive protein (CRP).
Methods.
Participants aged 20 and older in 2001–2006 National Health and Nutrition Examination Surveys (n = 8,655) with measures of serum 25(OH)D, CRP, hemoglobin A1c, and other important covariates were included in the present study.
Logistic regression and path analysis methods were applied to test the study hypotheses.
Results.
Decreased serum 25(OH)D concentration was significantly associated with increased odds of T2DM.
In males, an estimated 14.9% of the association between 25(OH)D and hemoglobin A1c was mediated by serum CRP.
However, this mediation effect was not observed in females.
Conclusion.
Using a nationally representative sample, the present study extends previous research and provides new evidence that the effect of decreased serum vitamin D concentration on T2DM may proceed through increased systemic inflammation in males.
Longitudinal studies and randomized control trials are needed to confirm the present findings.
American Psychological Association (APA)
Kabadi, Shaum M.& Liu, Longjian& Auchincloss, Amy H.& Zakeri, Issa F.. 2013. Multivariate Path Analysis of Serum 25-Hydroxyvitamin D Concentration, Inflammation, and Risk of Type 2 Diabetes Mellitus. Disease Markers،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031201
Modern Language Association (MLA)
Kabadi, Shaum M.…[et al.]. Multivariate Path Analysis of Serum 25-Hydroxyvitamin D Concentration, Inflammation, and Risk of Type 2 Diabetes Mellitus. Disease Markers No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1031201
American Medical Association (AMA)
Kabadi, Shaum M.& Liu, Longjian& Auchincloss, Amy H.& Zakeri, Issa F.. Multivariate Path Analysis of Serum 25-Hydroxyvitamin D Concentration, Inflammation, and Risk of Type 2 Diabetes Mellitus. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031201
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031201