![](/images/graphics-bg.png)
Role of Immunomarkers in the Clinicopathological Analysis of Unicystic Ameloblastoma
Joint Authors
Sah, Parul
Kamath, Asha
Chandrashekar, Chetana
Carnelio, Sunitha
Menon, Aparna
Radhakrishnan, Raghu
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
The clinical behavior of unicystic ameloblastoma varies according to its subtype.
The assessment of its proliferative capacity, neovascularization, and invasiveness using relevant immunomarkers may aid in appropriate surgical therapeutic protocol.
Methods.
18 cases of clinically and histologically confirmed unicystic ameloblastoma, categorized as luminal, intraluminal, or mural subtypes, were analyzed retrospectively.
Immunomarkers such as Ki-67, CD34, MMP-2, and MMP-9 were studied to evaluate their behavior.
Results.
Labeling index of Ki-67 was 4.25% in the intraluminal subtype, compared with 2.14% in the luminal and 4.04% in the mural variant (P=0.3).
CD34 immunostaining was significantly higher in the mural variant (43 per high power field) than the other two subtypes (P=0.04).
MMP-2 and MMP-9 were strongly expressed in mural, moderately in intraluminal, and weakly to absent in luminal variant.
Conclusions.
High proliferative index, angiogenesis, and protease activity in the mural ameloblastoma, ascertained by the expression of these markers, confirm its aggressive phenotype.
The intraluminal and luminal subtype exhibiting decreased expression are compatible with their indolent clinical behavior.
American Psychological Association (APA)
Sah, Parul& Menon, Aparna& Kamath, Asha& Chandrashekar, Chetana& Carnelio, Sunitha& Radhakrishnan, Raghu. 2013. Role of Immunomarkers in the Clinicopathological Analysis of Unicystic Ameloblastoma. Disease Markers،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1031202
Modern Language Association (MLA)
Sah, Parul…[et al.]. Role of Immunomarkers in the Clinicopathological Analysis of Unicystic Ameloblastoma. Disease Markers No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1031202
American Medical Association (AMA)
Sah, Parul& Menon, Aparna& Kamath, Asha& Chandrashekar, Chetana& Carnelio, Sunitha& Radhakrishnan, Raghu. Role of Immunomarkers in the Clinicopathological Analysis of Unicystic Ameloblastoma. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1031202
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031202