Neutrophil Gelatinase-Associated Lipocalin: Its Response to Hypoxia and Association with Acute Mountain Sickness
Joint Authors
Turner, Steve
Mellor, Adrian
Boos, Christopher
Stacey, Mike
Hooper, Tim
Smith, Chris
Begley, Joe
Yarker, Jo
Piper, Rick
O'Hara, John
King, Rod
Woods, David R.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Acute Mountain Sickness (AMS) is a common clinical challenge at high altitude (HA).
A point-of-care biochemical marker for AMS could have widespread utility.
Neutrophil gelatinase-associated lipocalin (NGAL) rises in response to renal injury, inflammation and oxidative stress.
We investigated whether NGAL rises with HA and if this rise was related to AMS, hypoxia or exercise.
NGAL was assayed in a cohort (n=22) undertaking 6 hours exercise at near sea-level (SL); a cohort (n=14) during 3 hours of normobaric hypoxia (FiO2 11.6%) and on two trekking expeditions (n=52) to over 5000 m.
NGAL did not change with exercise at SL or following normobaric hypoxia.
During the trekking expeditions NGAL levels (ng/ml, mean ± sd, range) rose significantly (P<0.001) from 68 ± 14 (60–102) at 1300 m to 183 ± 107 (65–519); 143 ± 66 (60–315) and 150 ± 71 (60–357) at 3400 m, 4270 m and 5150 m respectively.
At 5150 m there was a significant difference in NGAL between those with severe AMS (n=7), mild AMS (n=16) or no AMS (n=23): 201 ± 34 versus 171 ± 19 versus 124 ± 12 respectively (P=0.009 for severe versus no AMS; P=0.026 for mild versus no AMS).
In summary, NGAL rises in response to prolonged hypobaric hypoxia and demonstrates a relationship to the presence and severity of AMS.
American Psychological Association (APA)
Mellor, Adrian& Boos, Christopher& Stacey, Mike& Hooper, Tim& Smith, Chris& Begley, Joe…[et al.]. 2013. Neutrophil Gelatinase-Associated Lipocalin: Its Response to Hypoxia and Association with Acute Mountain Sickness. Disease Markers،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031210
Modern Language Association (MLA)
Mellor, Adrian…[et al.]. Neutrophil Gelatinase-Associated Lipocalin: Its Response to Hypoxia and Association with Acute Mountain Sickness. Disease Markers No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1031210
American Medical Association (AMA)
Mellor, Adrian& Boos, Christopher& Stacey, Mike& Hooper, Tim& Smith, Chris& Begley, Joe…[et al.]. Neutrophil Gelatinase-Associated Lipocalin: Its Response to Hypoxia and Association with Acute Mountain Sickness. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031210
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031210