High Frequency of a Single Nucleotide Substitution (c.-6-180T>G) of the Canine MDR1ABCB1 Gene Associated with Phenobarbital-Resistant Idiopathic Epilepsy in Border Collie Dogs
Joint Authors
Mizukami, Keijiro
Yabuki, Akira
Uddin, Mohammad Mejbah
Rahman, Mohammad Mahbubur
Kushida, Kazuya
Kohyama, Moeko
Chang, Hye-Sook
Yamato, Osamu
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-05
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
A single nucleotide substitution (c.-6-180T>G) associated with resistance to phenobarbital therapy has been found in the canine MDR1/ABCB1 gene in Border Collies with idiopathic epilepsy.
In the present study, a PCR-restriction fragment length polymorphism assay was developed for genotyping this mutation, and a genotyping survey was carried out in a population of 472 Border Collies in Japan to determine the current allele frequency.
The survey demonstrated the frequencies of the T/T wild type, T/G heterozygote, and G/G mutant homozygote to be 60.0%, 30.3%, and 9.8%, respectively, indicating that the frequency of the mutant G allele is extremely high (24.9%) in Border Collies.
The results suggest that this high mutation frequency of the mutation is likely to cause a high prevalence of phenobarbital-resistant epilepsy in Border Collies.
American Psychological Association (APA)
Mizukami, Keijiro& Yabuki, Akira& Chang, Hye-Sook& Uddin, Mohammad Mejbah& Rahman, Mohammad Mahbubur& Kushida, Kazuya…[et al.]. 2013. High Frequency of a Single Nucleotide Substitution (c.-6-180T>G) of the Canine MDR1ABCB1 Gene Associated with Phenobarbital-Resistant Idiopathic Epilepsy in Border Collie Dogs. Disease Markers،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1031218
Modern Language Association (MLA)
Mizukami, Keijiro…[et al.]. High Frequency of a Single Nucleotide Substitution (c.-6-180T>G) of the Canine MDR1ABCB1 Gene Associated with Phenobarbital-Resistant Idiopathic Epilepsy in Border Collie Dogs. Disease Markers No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-1031218
American Medical Association (AMA)
Mizukami, Keijiro& Yabuki, Akira& Chang, Hye-Sook& Uddin, Mohammad Mejbah& Rahman, Mohammad Mahbubur& Kushida, Kazuya…[et al.]. High Frequency of a Single Nucleotide Substitution (c.-6-180T>G) of the Canine MDR1ABCB1 Gene Associated with Phenobarbital-Resistant Idiopathic Epilepsy in Border Collie Dogs. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1031218
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031218