Markers of Increased Cardiovascular Risk in Postmenopausal Women: Focus on Oxidized-LDL and HDL Subpopulations
Joint Authors
Teixeira, Frederico
Sereno, José
Mascarenhas-Melo, Filipa
Teixeira de Lemos, Edite
Ribeiro, Sandra
Cotterill, Ethan
Rocha-Pereira, Petronila
Reis, Flávio
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objective.
To evaluate the effect of gender and menopause in cardiovascular risk (CVR) in a healthy population based on both classical and nontraditional markers.
Methods.
56 men and 68 women (48 pre- and 20 postmenopause) were enrolled in the study.
The following markers were analyzed: blood pressure (BP), body mass index (BMI), waist circumference (WC), glucose, total cholesterol (total-c), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-c), oxidized-LDL (Ox-LDL), HDL-c and subpopulations, paraoxonase-1 activity, hsCRP, uric acid, tumor necrosis factor alpha (TNF-α), adiponectin, vascular endothelial growth factor (VEGF), and intercellular adhesion molecular 1 (ICAM1).
Results.
Relative to the women, men present significantly increased BMI, WC, BP, glucose, total-c, TGs, LDL-c, Ox-LDL, uric acid, and TNF-α and reduced adiponectin and total and large HDL-c.
The protective profile of women is lost after menopause with a significantly increased BMI, WC, BP, glucose, LDL-c, Ox-LDL, hsCRP, and VEGF and decreased total and large HDL-c.
Significant correlations were found in women population and in postmenopausal women between Ox-LDL and total, large, and small HDL-c and between TNF-α and total, large, and small HDL-c, LDL-c, and Ox-LDL.
Conclusions.
Men present higher CVR than women who lost protection after menopause, evidenced by nontraditional markers, including Ox-LDL and HDL subpopulations.
American Psychological Association (APA)
Mascarenhas-Melo, Filipa& Sereno, José& Teixeira de Lemos, Edite& Ribeiro, Sandra& Rocha-Pereira, Petronila& Cotterill, Ethan…[et al.]. 2013. Markers of Increased Cardiovascular Risk in Postmenopausal Women: Focus on Oxidized-LDL and HDL Subpopulations. Disease Markers،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1031221
Modern Language Association (MLA)
Mascarenhas-Melo, Filipa…[et al.]. Markers of Increased Cardiovascular Risk in Postmenopausal Women: Focus on Oxidized-LDL and HDL Subpopulations. Disease Markers No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1031221
American Medical Association (AMA)
Mascarenhas-Melo, Filipa& Sereno, José& Teixeira de Lemos, Edite& Ribeiro, Sandra& Rocha-Pereira, Petronila& Cotterill, Ethan…[et al.]. Markers of Increased Cardiovascular Risk in Postmenopausal Women: Focus on Oxidized-LDL and HDL Subpopulations. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1031221
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031221