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Association between Angiotensin II Type 1 Receptor Polymorphism and Sudden Cardiac Death in Myocardial Infarction
Joint Authors
Pecháňová, Olga
Kovacova, Gabriela
Balogh, Stefan
Kruzliak, Peter
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
The renin-angiotensin system is involved in the pathogenesis of coronary artery disease and myocardial infarction (MI).
Angiotensin II (Ang II) has many adverse effects such as vasoconstriction and vascular remodeling, and these actions are mediated by the angiotensin II type 1 receptor (AT1R).
Patients and Methods.
A total of 1376 patients were recruited from January 2010 to April 2012.
The study group consisted of 749 patients with ACS (317 females and 432 males) and of 627 healthy controls.
Results.
The ACS patients demonstrated a lower proportion of AA genotypes and AC genotypes but higher proportions of CC genotypes than the control population.
The AT1R CC genotype conferred a 2.76-fold higher risk of MI compared with the genotype AC and AA.
In addition, the CC genotype was also associated with a 4.08 times higher risk of left anterior descending artery infarction and a 3.07 times higher risk of anterior wall infarction.
We also found that the CC genotype was independently associated with sudden cardiac death.
In Summary.
This study demonstrated that the AT1R CC genotype is an independent risk factor for ACS incidence, and this genotype is associated with a greater ACS severity and greater risk of sudden cardiac death.
American Psychological Association (APA)
Kruzliak, Peter& Kovacova, Gabriela& Pecháňová, Olga& Balogh, Stefan. 2013. Association between Angiotensin II Type 1 Receptor Polymorphism and Sudden Cardiac Death in Myocardial Infarction. Disease Markers،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031222
Modern Language Association (MLA)
Kruzliak, Peter…[et al.]. Association between Angiotensin II Type 1 Receptor Polymorphism and Sudden Cardiac Death in Myocardial Infarction. Disease Markers No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1031222
American Medical Association (AMA)
Kruzliak, Peter& Kovacova, Gabriela& Pecháňová, Olga& Balogh, Stefan. Association between Angiotensin II Type 1 Receptor Polymorphism and Sudden Cardiac Death in Myocardial Infarction. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031222
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031222