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Micropapillary Pattern at the Invasive Front and Its Association with Unresectable Colorectal Carcinomas
Joint Authors
Akimoto, Naohiko
Mitomi, Hiroyuki
Ichikawa, Kazuhito
Tomita, Shigeki
Tatsuguchi, Atsushi
Fujimori, Shunji
Naito, Zenya
Fujimori, Takahiro
Sakamoto, Choitsu
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Unresectable colorectal carcinomas (CRCs) as considered incurable even if the primary tumors and the metastatic ones can undergo resection are correlated with poor prognosis.
We evaluated the association between micropapillary pattern at the invasive front and unresectable CRCs.
Thirty-four out of 264 (12.9%) CRC patients with stages III and IV were unresectable cases.
The patients with unresectable CRCs had significantly worse survival than those with resectable CRCs (P<0.001).
Micropapillary pattern was evident in 12 (4.5%) out of 264 cases.
This pattern was observed in 6 of 34 (17.6%) unresectable CRCs and in 6 of 230 (2.6%) resectable cases (P=0.002).
Unresectable CRCs revealed more frequently deeper invasion (odds ratio (OR), 1.175; 95% confidence interval (CI), 1.113–1.241), lymph node metastasis (OR, 2.356; 95% CI, 1.132–4.905), and presence of micropapillary pattern at the invasive front (OR, 8.000; 95% CI, 2.415–26.504) as compared to resectable cases.
By multivariable logistic regression analysis, only micropapillary pattern was shown to be an independent predictor of unresectable CRCs (OR, 9.451; 95% CI, 2.468–36.196; P<0.001).
In conclusion, micropapillary pattern at the invasive front is associated with unresectable CRCs, and detection of it could help identify unresectable CRC cases.
American Psychological Association (APA)
Akimoto, Naohiko& Fujimori, Takahiro& Mitomi, Hiroyuki& Ichikawa, Kazuhito& Tomita, Shigeki& Tatsuguchi, Atsushi…[et al.]. 2013. Micropapillary Pattern at the Invasive Front and Its Association with Unresectable Colorectal Carcinomas. Disease Markers،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1031228
Modern Language Association (MLA)
Akimoto, Naohiko…[et al.]. Micropapillary Pattern at the Invasive Front and Its Association with Unresectable Colorectal Carcinomas. Disease Markers No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1031228
American Medical Association (AMA)
Akimoto, Naohiko& Fujimori, Takahiro& Mitomi, Hiroyuki& Ichikawa, Kazuhito& Tomita, Shigeki& Tatsuguchi, Atsushi…[et al.]. Micropapillary Pattern at the Invasive Front and Its Association with Unresectable Colorectal Carcinomas. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1031228
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031228