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Serum Levels of Selected Th17 and Th22 Cytokines in Psoriatic Patients
Joint Authors
Michalak-Stoma, Anna
Gerkowicz, Agnieszka
Bartosińska, Joanna
Juszkiewicz-Borowiec, Maria
Chodorowska, Grażyna
Kowal, Małgorzata
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Psoriasis is a T cell-mediated inflammatory disease in which pathogenesis T helper (Th) lymphocytes (Th1, Th17, and Th22) play an important role.
The aim of the study was to assess the serum levels of some cytokines involved in the Th17 and Th22 responses in psoriatic patients.
Material and Methods.
The study comprised 60 psoriatic patients and 30 healthy controls.
In the serum collected from psoriatic patients and healthy controls, the concentrations of IL-6, IL-12, IL-17, IL-20, IL-22, and IL-23 were examined with ELISA kits.
Severity of psoriatic skin lesions was assessed by means of PASI, BSA, and PGA scores.
Results.
IL-6, IL-20, and IL-22 concentrations were significantly higher in psoriatic patients in comparison with the control group.
The positive correlations between the concentrations of IL-22 and IL-20 and severity of psoriasis assessed with PASI and BSA scores as well as IL-17 and PASI score were found.
There was also a positive correlation between IL-23 and IL-17 concentrations.
Conclusions.
Results of the conducted studies suggest that Th22 response may contribute to the skin and systemic inflammatory disease in psoriasis.
It seems that early identification of soluble biomarkers and initiation of well-matched treatment may prevent exacerbation and progression of psoriasis.
American Psychological Association (APA)
Michalak-Stoma, Anna& Bartosińska, Joanna& Kowal, Małgorzata& Juszkiewicz-Borowiec, Maria& Gerkowicz, Agnieszka& Chodorowska, Grażyna. 2013. Serum Levels of Selected Th17 and Th22 Cytokines in Psoriatic Patients. Disease Markers،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031230
Modern Language Association (MLA)
Michalak-Stoma, Anna…[et al.]. Serum Levels of Selected Th17 and Th22 Cytokines in Psoriatic Patients. Disease Markers No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1031230
American Medical Association (AMA)
Michalak-Stoma, Anna& Bartosińska, Joanna& Kowal, Małgorzata& Juszkiewicz-Borowiec, Maria& Gerkowicz, Agnieszka& Chodorowska, Grażyna. Serum Levels of Selected Th17 and Th22 Cytokines in Psoriatic Patients. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031230
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031230