Plasma Gamma-Glutamyltransferase Is Strongly Determined by Acylation Stimulating Protein Levels Independent of Insulin Resistance in Patients with Acute Coronary Syndrome
Joint Authors
Saleh, Jumana
Farhan, Hatem
Al-Saqri, Ibtisam
Al-Riyami, Bashair
Cianflone, Katherine
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Steatosis is a manifestation of the metabolic syndrome often associated with release of liver enzymes and inflammatory adipocytokines linked to cardiovascular risk.
Gamma-glutamyltransferase (GGT) is one sensitive liver marker recently identified as an independent cardiovascular risk factor.
Mechanisms involved in enhanced hepatic lipogenesis causing steatosis are not yet identified and are usually linked to insulin resistance (IR).
Acylation stimulating protein (ASP), a potent lipogenic factor, was recently shown to increase in patients with steatosis and was implicated in its pathogenesis.
Aim.
To investigate the association of plasma ASP levels with liver and metabolic risk markers in acute coronary syndrome (ACS) patients.
Methods.
28 patients and 30 healthy controls were recruited.
Their anthropometrics, lipid profile, liver markers, insulin, and ASP levels were measured.
Results.
In the patients, ASP, liver, and metabolic risk markers were markedly higher than in the controls.
ASP strongly predicted GGT levels (B=0.75, P<0.0001), followed by triglycerides (B=0.403, P=0.017), together determining 57.6% variation in GGT levels.
Insulin and IR correlated with metabolic risk components but not with liver enzymes.
Conclusion.
The strong association of ASP with GGT in ACS patients suggests that ASP, independent of IR, may contribute to a vicious cycle of hepatic lipogenic stimulation and GGT release promoting atherogenesis.
American Psychological Association (APA)
Saleh, Jumana& Farhan, Hatem& Al-Saqri, Ibtisam& Al-Riyami, Bashair& Cianflone, Katherine. 2013. Plasma Gamma-Glutamyltransferase Is Strongly Determined by Acylation Stimulating Protein Levels Independent of Insulin Resistance in Patients with Acute Coronary Syndrome. Disease Markers،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031236
Modern Language Association (MLA)
Saleh, Jumana…[et al.]. Plasma Gamma-Glutamyltransferase Is Strongly Determined by Acylation Stimulating Protein Levels Independent of Insulin Resistance in Patients with Acute Coronary Syndrome. Disease Markers No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1031236
American Medical Association (AMA)
Saleh, Jumana& Farhan, Hatem& Al-Saqri, Ibtisam& Al-Riyami, Bashair& Cianflone, Katherine. Plasma Gamma-Glutamyltransferase Is Strongly Determined by Acylation Stimulating Protein Levels Independent of Insulin Resistance in Patients with Acute Coronary Syndrome. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031236
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031236