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The Role of T Helper (TH)17 Cells as a Double-Edged Sword in the Interplay of Infection and Autoimmunity with a Focus on Xenobiotic-Induced Immunomodulation
Joint Authors
Hemdan, Nasr Y. A.
Sack, Ulrich
Abu El-Saad, Ahmed M.
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Extensive research in recent years suggests that exposure to xenobiotic stimuli plays a critical role in autoimmunity induction and severity and that the resulting response would be exacerbated in individuals with an infection-aroused immune system.
In this context, heavy metals constitute a prominent category of xenobiotic substances, known to alter divergent immune cell responses in accidentally and occupationally exposed individuals, thereby increasing the susceptibility to autoimmunity and cancer, especially when accompanied by inflammation-triggered persistent sensitization.
This perception is learned from experimental models of infection and epidemiologic studies and clearly underscores the interplay of exposure to such immunomodulatory elements with pre- or postexposure infectious events.
Further, the TH17 cell subset, known to be associated with a growing list of autoimmune manifestations, may be the “superstar” at the interface of xenobiotic exposure and autoimmunity.
In this review, the most recently established links to this nomination are short-listed to create a framework to better understand new insights into TH17’s contributions to autoimmunity.
American Psychological Association (APA)
Hemdan, Nasr Y. A.& Abu El-Saad, Ahmed M.& Sack, Ulrich. 2013. The Role of T Helper (TH)17 Cells as a Double-Edged Sword in the Interplay of Infection and Autoimmunity with a Focus on Xenobiotic-Induced Immunomodulation. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1031276
Modern Language Association (MLA)
Hemdan, Nasr Y. A.…[et al.]. The Role of T Helper (TH)17 Cells as a Double-Edged Sword in the Interplay of Infection and Autoimmunity with a Focus on Xenobiotic-Induced Immunomodulation. Journal of Immunology Research No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-1031276
American Medical Association (AMA)
Hemdan, Nasr Y. A.& Abu El-Saad, Ahmed M.& Sack, Ulrich. The Role of T Helper (TH)17 Cells as a Double-Edged Sword in the Interplay of Infection and Autoimmunity with a Focus on Xenobiotic-Induced Immunomodulation. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1031276
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031276