Roles of γδ T Cells in the Pathogenesis of Autoimmune Diseases
Joint Authors
Li, Xia
Su, Ding-Lei
Shen, Min-Ning
Sun, Ling-Yun
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
γ δ T cells are a minor population of T cells that express the TCR γδ chains, mainly distributed in the mucosal and epithelial tissue and accounting for less than 5% of the total T cells in the peripheral blood.
By bridging innate and adaptive immunity, γδ T cells play important roles in the anti-infection, antitumor, and autoimmune responses.
Previous research on γδ T cells was primarily concentrated on infectious diseases and tumors, whereas their functions in autoimmune diseases attracted much attention.
In this paper, we summarized the various functions of γδ T cells in two prototypical autoimmune connective tissue diseases, that is, SLE and RA, elaborating on their antigen-presenting capacity, secretion of proinflammatory cytokines, immunomodulatory effects, and auxiliary function for B cells, which contribute to overproduction of proinflammatory cytokines and pathogenic autoantibodies, ultimately leading to the onset of these autoimmune diseases.
Elucidation of the roles of γδ T cells in autoimmune diseases is not only conducive to in-depth understanding of the pathogenesis of these diseases, but also beneficial in providing theoretical support for the development of γδ T-cell-targeted therapy.
American Psychological Association (APA)
Su, Ding-Lei& Shen, Min-Ning& Li, Xia& Sun, Ling-Yun. 2013. Roles of γδ T Cells in the Pathogenesis of Autoimmune Diseases. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031296
Modern Language Association (MLA)
Su, Ding-Lei…[et al.]. Roles of γδ T Cells in the Pathogenesis of Autoimmune Diseases. Journal of Immunology Research No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1031296
American Medical Association (AMA)
Su, Ding-Lei& Shen, Min-Ning& Li, Xia& Sun, Ling-Yun. Roles of γδ T Cells in the Pathogenesis of Autoimmune Diseases. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031296
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031296