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Polymeric Nanosuspensions for Enhanced Dissolution of Water Insoluble Drugs
Joint Authors
Vasilev, Krasimir
Yadollahi, Roya
Prestidge, Clive A.
Simovic, Spomenka
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aim of the present research is to formulate and evaluate polymeric nanosuspensions containing three model water insoluble drugs, nifedipine (NIF), carbamazepine (CBZ), and ibuprofen (IBU) with various physicochemical properties.
The nanosuspensions were prepared from hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) by a cosolvent technique with polyethylene glycol (PEG-300) and water as the cosolvents.
Physicochemical and morphological characteristics of the nanosuspensions (particle size, polydispersity index, and crystallinity) have been correlated with the drug release behaviour.
The effects of polymer, drug ratio on the physical, morphological, and dissolution characteristics of the drugs are reported.
Drug release is significantly enhanced from the nanosuspensions; for example, the maximum NIF, IBU, and CBZ concentrations after 8-hour dissolution are increased approximately 37, 2, and 1.2 times, respectively, in comparison with the pure powdered drugs.
Based on this solubilization enhancement performance, the nanosuspensions have potential for increasing the orally dosed bioavailability of NIF, IBU, and CBZ.
American Psychological Association (APA)
Yadollahi, Roya& Vasilev, Krasimir& Prestidge, Clive A.& Simovic, Spomenka. 2013. Polymeric Nanosuspensions for Enhanced Dissolution of Water Insoluble Drugs. Journal of Nanomaterials،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1031314
Modern Language Association (MLA)
Yadollahi, Roya…[et al.]. Polymeric Nanosuspensions for Enhanced Dissolution of Water Insoluble Drugs. Journal of Nanomaterials No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1031314
American Medical Association (AMA)
Yadollahi, Roya& Vasilev, Krasimir& Prestidge, Clive A.& Simovic, Spomenka. Polymeric Nanosuspensions for Enhanced Dissolution of Water Insoluble Drugs. Journal of Nanomaterials. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1031314
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031314