Enhanced Intracellular Uptake of CdTe Quantum Dots by Conjugation of Oligopeptides
Joint Authors
Choi, Moon-Jeong
Chang, Yongmin
Guo, Haiquing
Rathinaraj, Pierson
Kang, Inn-Kyu
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Arg-Gly-Asp-Ser (RGDS), a typical membrane-permeable carrier peptide, was conjugated with mercaptoisobutyric acid-immobilized CdTe quantum dot (CTNPs) to enhance the intracellular uptake of quantum dots.
Mean size of mercaptoisobutyric acid-immobilized quantum dots (37 nm) as determined by dynamic light scattering was increased up to 54 nm after RGDS immobilization.
It was found, from in vitro cell culture experiment, that fibroblast (NIH 3T3) cells were well proliferated in the presence of RGDS-conjugated quantum dots (RCTNPs), and the intracellular uptake of CTNPs and RCTNPs was studied by means of ICP and fluorescence microscopy.
As a result, the RCTNPs specifically bound to the membrane of NIH 3T3 cells and almost saturated after 6 hours incubation.
The amount of RCTNPs uptaken by the cells was higher than that of CTNPs, demonstrating the enhancing effect of RGDS peptide conjugation on the intracellular uptake of quantum dots (QDs).
American Psychological Association (APA)
Choi, Moon-Jeong& Rathinaraj, Pierson& Chang, Yongmin& Guo, Haiquing& Kang, Inn-Kyu. 2013. Enhanced Intracellular Uptake of CdTe Quantum Dots by Conjugation of Oligopeptides. Journal of Nanomaterials،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1031333
Modern Language Association (MLA)
Choi, Moon-Jeong…[et al.]. Enhanced Intracellular Uptake of CdTe Quantum Dots by Conjugation of Oligopeptides. Journal of Nanomaterials No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1031333
American Medical Association (AMA)
Choi, Moon-Jeong& Rathinaraj, Pierson& Chang, Yongmin& Guo, Haiquing& Kang, Inn-Kyu. Enhanced Intracellular Uptake of CdTe Quantum Dots by Conjugation of Oligopeptides. Journal of Nanomaterials. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1031333
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031333