Titanium Dioxide Nanoparticles Induced Proinflammation of Primary Cultured Cardiac Myocytes of Rat
Joint Authors
Song, Wei
Li, Zhou
Fan, Yubo
Wang, Jiangxue
Li, Ping
Zhou, Gang
Liu, Meili
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Titanium dioxide (TiO2) nanoparticles are widely used in electronics, biology, and medicine owing to their special properties.
However, during TiO2 nanoparticles exposure, nanoparticles may enter the blood circulation and translocate to the heart, and they may result in negative effects on the cardiovascular system.
In this study, we demonstrated that the anatase and rutile TiO2 nanoparticles had potential toxicological effects on primary cultured cardiac myocytes of rat.
After incubating with the anatase and rutile TiO2 nanoparticles, the primary cultured cardiac myocytes had become elongated and appeared to detach from the surface of cell plate.
After exposure to 50, 100, and 150 μg/mL anatase and rutile TiO2 nanoparticles for 2 days, the obvious decrease of cell viability was observed.
And further studies showed that TiO2 nanoparticles exposure could induce the high expression of proinflammatory cytokines TNF-α and IL-6, especially in 150 μg/mL group.
The long-rod rutile TiO2 had more strong effects on cell viability and proinflammatory cytokines induction than red-blood cells like anatase TiO2.
Results indicated that TiO2 nanoparticles exposure could impair the function of primary cultured cardiac myocytes of rat.
Therefore, these findings support the view that much more attention should be aroused on the application of these nanoparticles and their potential exposure effects on human beings.
American Psychological Association (APA)
Song, Wei& Wang, Jiangxue& Liu, Meili& Li, Ping& Zhou, Gang& Li, Zhou…[et al.]. 2013. Titanium Dioxide Nanoparticles Induced Proinflammation of Primary Cultured Cardiac Myocytes of Rat. Journal of Nanomaterials،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1031344
Modern Language Association (MLA)
Song, Wei…[et al.]. Titanium Dioxide Nanoparticles Induced Proinflammation of Primary Cultured Cardiac Myocytes of Rat. Journal of Nanomaterials No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1031344
American Medical Association (AMA)
Song, Wei& Wang, Jiangxue& Liu, Meili& Li, Ping& Zhou, Gang& Li, Zhou…[et al.]. Titanium Dioxide Nanoparticles Induced Proinflammation of Primary Cultured Cardiac Myocytes of Rat. Journal of Nanomaterials. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1031344
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031344