Fabrication of Pamidronic Acid-Immobilized TiO2Hydroxyapatite Composite Nanofiber Mats for Biomedical Applications

Abstract EN

TiO2/hydroxyapatite (TiO2/HA) composite nanofiber mats were fabricated using an electrospinning technique.

Subsequently, pamidronic acid (PDA) was immobilized on the surface of the TiO2/HA nanofiber mat to improve osseointegration.

X-ray photoelectron microscopy and scanning electron microscopy (SEM) were used to characterize the structure and morphology of the PDA-immobilized TiO2/HA composite nanofiber mat (TiO2/HA-P).

The potential of TiO2/HA-P as a bone scaffold was assessed by examining the cell adhesion and proliferation of osteoblasts and osteoclasts.

The adhesion and proliferation of osteoblasts on the TiO2/HA-P composite nanofiber mat were slightly higher than those on the TiO2/HA composite nanofiber mat, whereas the viability of osteoclasts on the TiO2/HA-P nanofiber mat was significantly suppressed.

These results suggest that the TiO2/HA-P nanofiber mat has the potential for use as a therapeutic bone implant.