Iron Oxide Magnetic Nanoparticles: Characterization and Toxicity Evaluation by In Vitro and In Vivo Assays
Joint Authors
Ciobanu, C. S.
Stoicea, Mihai
Predoi, Daniela
Prodan, Alina Mihaela
Chifiriuc, Mariana Carmen
Iconaru, Simona Liliana
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aim of this study was to evaluate the biological properties of iron oxide nanoparticles (IO-NPs) obtained in the aqueous suspension.
The iron oxide nanoparticles were characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM).
The biocompatibility of the iron oxide was demonstrated by the in vitro quantification of HeLa cells viability using propidium iodide (PI) and fluorescein diacetate (FdA) and the MTT colorimetric assay.
The toxicity of small size iron oxide nanoparticles was also evaluated by means of histological examination on male Brown Norway rats after intraperitoneal injection.
At the tested concentrations, the nanoparticles proved to be not cytotoxic on HeLa cells.
The rat’s behavior, as well as the histopathological aspect of liver, kidney, lung, and spleen tissues at 48 h after intraperitoneal injection did not present any modifications.
The in vivo and in vitro assays suggested that the IO-NPs could be further used for developing new in vivo medical applications.
American Psychological Association (APA)
Prodan, Alina Mihaela& Iconaru, Simona Liliana& Ciobanu, C. S.& Chifiriuc, Mariana Carmen& Stoicea, Mihai& Predoi, Daniela. 2013. Iron Oxide Magnetic Nanoparticles: Characterization and Toxicity Evaluation by In Vitro and In Vivo Assays. Journal of Nanomaterials،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1031448
Modern Language Association (MLA)
Prodan, Alina Mihaela…[et al.]. Iron Oxide Magnetic Nanoparticles: Characterization and Toxicity Evaluation by In Vitro and In Vivo Assays. Journal of Nanomaterials No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1031448
American Medical Association (AMA)
Prodan, Alina Mihaela& Iconaru, Simona Liliana& Ciobanu, C. S.& Chifiriuc, Mariana Carmen& Stoicea, Mihai& Predoi, Daniela. Iron Oxide Magnetic Nanoparticles: Characterization and Toxicity Evaluation by In Vitro and In Vivo Assays. Journal of Nanomaterials. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1031448
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031448