Fabrication of Novel Biodegradable α-Tricalcium Phosphate Cement Set by Chelating Capability of Inositol Phosphate and Its Biocompatibility
Joint Authors
Konishi, Toshiisa
Mizumoto, Minori
Honda, Michiyo
Horiguchi, Yukiko
Oribe, Kazuya
Morisue, Hikaru
Aizawa , Mamoru
Toyama, Yoshiaki
Matsumoto, Morio
Ishii, Ken
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Biodegradable α-tricalcium phosphate (α-TCP) cement based on the chelate-setting mechanism of inositol phosphate (IP6) was developed.
This paper examined the effect of the milling time of α-TCP powder on the material properties of the cement.
In addition, biocompatibility of the result cement in vitro using osteoblasts and in vivo using rabbit models will be studied as well.
The α-TCP powders were ballmilled using ZrO2 beads in pure water for various durations up to 270 minutes, with a single-phase α-TCP obtained at ballmilling for 120 minutes.
The resulting cement was mostly composed of α-TCP phase, and the compressive strength of the cement was 8.5±1.1 MPa, which suggested that the cements set with keeping the crystallite phase of starting cement powder.
The cell-culture test indicated that the resulting cements were biocompatible materials.
In vivo studies showed that the newly formed bones increased with milling time at a slight distance from the cement specimens and grew mature at 24 weeks, and the surface of the cement was resorbed by tartrate-resistant acid phosphatase-(TRAP-)positive osteoclast-like cells until 24 weeks of implantation.
The present α-TCP cement is promising for application as a novel paste-like artificial bone with biodegradability and osteoconductivity.
American Psychological Association (APA)
Konishi, Toshiisa& Mizumoto, Minori& Honda, Michiyo& Horiguchi, Yukiko& Oribe, Kazuya& Morisue, Hikaru…[et al.]. 2013. Fabrication of Novel Biodegradable α-Tricalcium Phosphate Cement Set by Chelating Capability of Inositol Phosphate and Its Biocompatibility. Journal of Nanomaterials،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1031600
Modern Language Association (MLA)
Konishi, Toshiisa…[et al.]. Fabrication of Novel Biodegradable α-Tricalcium Phosphate Cement Set by Chelating Capability of Inositol Phosphate and Its Biocompatibility. Journal of Nanomaterials No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1031600
American Medical Association (AMA)
Konishi, Toshiisa& Mizumoto, Minori& Honda, Michiyo& Horiguchi, Yukiko& Oribe, Kazuya& Morisue, Hikaru…[et al.]. Fabrication of Novel Biodegradable α-Tricalcium Phosphate Cement Set by Chelating Capability of Inositol Phosphate and Its Biocompatibility. Journal of Nanomaterials. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1031600
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031600