Evaluation of "myrrh extract" against schistosoma manosoni : a histological study
Joint Authors
Masud, Ahmad M. A.
al-Ebiary, Faiqah H.
Ibrahim, Suzi H.
Salih, Hanan A. A.
Khalil, Hazim H. M.
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 40, Issue 1 (30 Apr. 2010), pp.245-262, 18 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2010-04-30
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
This study investigated the effect of myrrh extract on different developmental stages of Schistosoma mansoni.
Sixty albino mice were used and divided into three main groups : GI (control group), GII (infected group) and GIII (infected treated group).
The last group was further divided into 3 subgroups where the drug was administered in a dose of 500mg / kg body weight for 5 days starting on the 1st day PI for IIIA, on the 21st day PI for IIIB and on the 45th day PI for IIIC.
A morphometric study was performed for the mean number and perimeter of granulomas.
In GII, typical bilharzial granulomas were frequently encountered in the portal tracts with numerous eosinophils, collagen fiber deposition and reticular fiber condensation.
Hepatocytes revealed vacuolation, nuclear affection and depletion of glycogen.
In GUI, granulomas were less frequently observed with apparent decrease of eosinophils.
The maximum effect of the drug was observed in SGs IIIB and IIIC as detected by significant decrease in the mean number and size of granulomas, paucity of eosinophils, decreased fibrosis and reticular fibers and the restoration of the glycogen content in the hepatocytes.
The present data proved that myrrh has a valuable schistosomicid-al effect against different stages of S.
mansoni.
This chemotherapeutic effect was more evident when the drug was given to infected mice on the 21st as well as on the 45th day PI.
American Psychological Association (APA)
Masud, Ahmad M. A.& al-Ebiary, Faiqah H.& Ibrahim, Suzi H.& Salih, Hanan A. A.& Khalil, Hazim H. M.. 2010. Evaluation of "myrrh extract" against schistosoma manosoni : a histological study. Journal of the Egyptian Society of Parasitology،Vol. 40, no. 1, pp.245-262.
https://search.emarefa.net/detail/BIM-103200
Modern Language Association (MLA)
Masud, Ahmad M. A.…[et al.]. Evaluation of "myrrh extract" against schistosoma manosoni : a histological study. Journal of the Egyptian Society of Parasitology Vol. 40, no. 1 (Apr. 2010), pp.245-262.
https://search.emarefa.net/detail/BIM-103200
American Medical Association (AMA)
Masud, Ahmad M. A.& al-Ebiary, Faiqah H.& Ibrahim, Suzi H.& Salih, Hanan A. A.& Khalil, Hazim H. M.. Evaluation of "myrrh extract" against schistosoma manosoni : a histological study. Journal of the Egyptian Society of Parasitology. 2010. Vol. 40, no. 1, pp.245-262.
https://search.emarefa.net/detail/BIM-103200
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 253-258
Record ID
BIM-103200