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Clinical Activity and Tolerability of a 14-Day Infusional Ifosfamide Schedule in Soft-Tissue Sarcoma
Joint Authors
Judson, Ian R.
Martin-Liberal, Juan
Linch, Mark
Mitchell, Scott
al-Muderis, Omar
Messiou, Christina
Miah, Aisha
Khabra, Komel
Alam, Salma
Benson, Charlotte
Jones, Robin L.
Olmos, David
Scurr, Michelle
Constantinidou, Anastasia
Fisher, Cyril
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Soft-tissue sarcomas (STS) are a heterogeneous group of diseases with lack of effective treatments in most cases.
Previous data suggest that continuous infusional ifosfamide regimens might improve cytotoxicity and tolerability compared to standard schedules.
Methods.
We retrospectively report the outcome of 35 patients affected by STS treated with a 14-day infusional ifosfamide regimen (1000 mg/m2/day) in our institution.
Predictive factors for toxicity were also explored.
Results.
Median age was 53 years.
There were 16 males and 19 females.
Classification by histology was dedifferentiated liposarcoma (DDLPS): 22 (62.8%), synovial sarcoma: 7 (20%), myxoid/round-cell liposarcoma: 3 (8.5%), and others: 3 (8.5%).
Overall, 7 patients (20%) achieved partial response (PR) and 10 patients (29%) achieved stable disease (SD).
DDLPS showed special sensitivity: 5 patients (22.7%) had PR, 7 patients (31.8%) had SD, and disease control rate was 54.5%.
Median progression-free survival and overall survival were 4.2 and 11.2 months, respectively.
The most common toxicities were fatigue, nausea, and vomiting (all grades: 85.7%, 83%, and 54.3%, resp.).
Neither hypoalbuminaemia nor gender was found to predict toxicity, although encephalopathy predominantly affected females.
Conclusion.
Ifosfamide administered as a 14-day continuous infusion is a safe regimen in STS with notable activity in DDLPS.
American Psychological Association (APA)
Martin-Liberal, Juan& Alam, Salma& Constantinidou, Anastasia& Fisher, Cyril& Khabra, Komel& Messiou, Christina…[et al.]. 2013. Clinical Activity and Tolerability of a 14-Day Infusional Ifosfamide Schedule in Soft-Tissue Sarcoma. Complexity،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1032538
Modern Language Association (MLA)
Martin-Liberal, Juan…[et al.]. Clinical Activity and Tolerability of a 14-Day Infusional Ifosfamide Schedule in Soft-Tissue Sarcoma. Complexity No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1032538
American Medical Association (AMA)
Martin-Liberal, Juan& Alam, Salma& Constantinidou, Anastasia& Fisher, Cyril& Khabra, Komel& Messiou, Christina…[et al.]. Clinical Activity and Tolerability of a 14-Day Infusional Ifosfamide Schedule in Soft-Tissue Sarcoma. Complexity. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1032538
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032538